Irish journal of medical science · 2007
Hypersplenism is related to age of onset of liver disease.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
McCormick P A, Walker S, Benepal R
Аннотация
BACKGROUND: The aim of this study was to investigate whether hypersplenism is related to the age of onset of liver disease.
METHODS: Hypersplenism was assessed in 84 consecutive cirrhotic patients attending a university hospital liver clinic.
RESULTS: Hypersplenism was present in 78% of patients and severe in 39%. Severe hypersplenism was more common in patients with cystic fibrosis liver disease (88%, P < 0.0001) and autoimmune hepatitis (60%, P = 0.0006) compared to alcoholic cirrhosis (12%). There was a significant correlation between patient age and platelet count r = 0.525, P < 0.0001 in the group as a whole and for the sub-group of patients with autoimmune hepatitis r = 0.54, P = 0.047. There was a negative correlation between age and spleen size r = -0.611, P < 0.0001.
CONCLUSION: Younger patients had lower platelet counts, larger spleens and a higher incidence of hypersplenism suggesting that hypersplenism is significantly related to the age of onset of chronic liver disease.
METHODS: Hypersplenism was assessed in 84 consecutive cirrhotic patients attending a university hospital liver clinic.
RESULTS: Hypersplenism was present in 78% of patients and severe in 39%. Severe hypersplenism was more common in patients with cystic fibrosis liver disease (88%, P < 0.0001) and autoimmune hepatitis (60%, P = 0.0006) compared to alcoholic cirrhosis (12%). There was a significant correlation between patient age and platelet count r = 0.525, P < 0.0001 in the group as a whole and for the sub-group of patients with autoimmune hepatitis r = 0.54, P = 0.047. There was a negative correlation between age and spleen size r = -0.611, P < 0.0001.
CONCLUSION: Younger patients had lower platelet counts, larger spleens and a higher incidence of hypersplenism suggesting that hypersplenism is significantly related to the age of onset of chronic liver disease.
Предметные рубрики MeSH
Age DistributionAge of OnsetAnalysis of VarianceBlood Chemical AnalysisCohort StudiesComorbidityConfidence IntervalsFemaleHumansHypersplenismLinear ModelsLiver CirrhosisLiver Function TestsMaleMiddle AgedPlatelet CountPrevalenceProbabilityPrognosisRisk AssessmentSeverity of Illness IndexSex DistributionSurvival Rate