The New Zealand medical journal · 2011
Off-label use of atypical antipsychotic medications in Canterbury, New Zealand.
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Monasterio Erik, McKean Andrew
Аннотация
AIM: To estimate the frequency and characteristics of "off-label" use of atypical antipsychotic medications (AAPs) by psychiatrists in Canterbury, New Zealand.
METHODS: Data on "off-label" prescribing of AAPs including the choice of medication, frequency of prescribing, and the indications for its use was collected using a postal survey of psychiatrists registered with the NZ Medical Council in the Canterbury region.
RESULTS: 48 psychiatrists (71%) completed the survey. Forty-six (96%) prescribed AAPs "off-label". By far the most common agent was quetiapine (94%). Twenty-eight respondents (58%) prescribed "off-label" at least once a week. The most common reasons for the use of these agents was: anxiety (89%), sedation (79%), post-traumatic stress disorder (57%), treatment augmentation of another antipsychotic agent (48%) and behavioural and psychological symptoms of dementia (33%).
CONCLUSION: "Off-label" prescribing, particularly of quetiapine is very common in the Canterbury region, despite little scientific evidence for this kind of use, increasing evidence of abuse and potential for significant side-effects.
METHODS: Data on "off-label" prescribing of AAPs including the choice of medication, frequency of prescribing, and the indications for its use was collected using a postal survey of psychiatrists registered with the NZ Medical Council in the Canterbury region.
RESULTS: 48 psychiatrists (71%) completed the survey. Forty-six (96%) prescribed AAPs "off-label". By far the most common agent was quetiapine (94%). Twenty-eight respondents (58%) prescribed "off-label" at least once a week. The most common reasons for the use of these agents was: anxiety (89%), sedation (79%), post-traumatic stress disorder (57%), treatment augmentation of another antipsychotic agent (48%) and behavioural and psychological symptoms of dementia (33%).
CONCLUSION: "Off-label" prescribing, particularly of quetiapine is very common in the Canterbury region, despite little scientific evidence for this kind of use, increasing evidence of abuse and potential for significant side-effects.