Zhonghua er bi yan hou ke za zhi · 2002
[Effects of mtDNA deletion associated with abnormal expression in rat cochlear with presbycusis].
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Wu Haiyan, Du Baodong, Wang Ping, Niu Chunbo, Jin Xin
Аннотация
OBJECTIVE: To investigate the effects of the common deletion (4834-bp) of mitochondrial DNA (mtDNA) in rat cochlear with presbycusis.
METHODS: The mtDNA 4834-bp deletion was analyzed by PCR. The mitochondrial-encoded cytochrome c oxidase subunit I (COXI) transcript level and cytochrome c oxidase (COX) activity were measured by RT-PCR and histochemical methods respectively.
RESULTS: The 4834-bp deletion occurred in all the senescent rat cochlear. The COXI transcript level was decreased associated with the decline of COX activity.
CONCLUSION: The mtDNA 4834-bp deletion presented in the rat cochlear with presbycusis, which lead to the decrease of COXI transcript level and COX activity, may play an important role in the pathogens of presbycusis.
METHODS: The mtDNA 4834-bp deletion was analyzed by PCR. The mitochondrial-encoded cytochrome c oxidase subunit I (COXI) transcript level and cytochrome c oxidase (COX) activity were measured by RT-PCR and histochemical methods respectively.
RESULTS: The 4834-bp deletion occurred in all the senescent rat cochlear. The COXI transcript level was decreased associated with the decline of COX activity.
CONCLUSION: The mtDNA 4834-bp deletion presented in the rat cochlear with presbycusis, which lead to the decrease of COXI transcript level and COX activity, may play an important role in the pathogens of presbycusis.