Brain imaging and behavior · 2025
Based on the resting-state functional magnetic resonance imaging reveals the causal relationship between the brain function network and the risk of tinnitus: a bidirectional Mendelian randomization analysis.
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Liu Yuchao, Li Chunli, Yao Linli, Tan Yuan, Shi Lu, Chen Pei
Аннотация
OBJECTIVES: Tinnitus affects millions worldwide. Its neural mechanisms remain unclear. This study aimed to explore the causal relationships between brain functional networks and tinnitus risk using Mendelian randomization (MR) analyses.
METHODS: We performed MR analyses using brain activity data from resting-state functional magnetic resonance imaging (rs-fMRI) and genetic data from genome-wide association studies (GWAS). A total of 191 brain features, including amplitude traits and functional connectivity measures, were selected based on their genetic associations.
RESULTS: Forward MR analyses showed that increased activity in the parietal and inferior frontal regions was associated with a 41% reduction in tinnitus risk (OR = 0.59, p = 1.8 × 10-4). In contrast, increased activity in the precuneus, angular gyrus, and frontal areas was linked to a 49% increase in tinnitus risk (OR = 1.49, p = 8.9 × 10-4). Activities in the parietal and inferior frontal regions were negatively correlated with tinnitus risk (OR = 0.72, p = 0.0037). Additionally, higher activity in the parietal, frontal, and temporal regions doubled the risk (OR = 2.02, p = 0.015). Reverse MR showed that stronger connectivity between frontal and temporal regions was inversely related to tinnitus risk (beta = - 0.056, p = 0.049).
CONCLUSIONS: Specific brain activity and connectivity patterns are causally linked to tinnitus.
METHODS: We performed MR analyses using brain activity data from resting-state functional magnetic resonance imaging (rs-fMRI) and genetic data from genome-wide association studies (GWAS). A total of 191 brain features, including amplitude traits and functional connectivity measures, were selected based on their genetic associations.
RESULTS: Forward MR analyses showed that increased activity in the parietal and inferior frontal regions was associated with a 41% reduction in tinnitus risk (OR = 0.59, p = 1.8 × 10-4). In contrast, increased activity in the precuneus, angular gyrus, and frontal areas was linked to a 49% increase in tinnitus risk (OR = 1.49, p = 8.9 × 10-4). Activities in the parietal and inferior frontal regions were negatively correlated with tinnitus risk (OR = 0.72, p = 0.0037). Additionally, higher activity in the parietal, frontal, and temporal regions doubled the risk (OR = 2.02, p = 0.015). Reverse MR showed that stronger connectivity between frontal and temporal regions was inversely related to tinnitus risk (beta = - 0.056, p = 0.049).
CONCLUSIONS: Specific brain activity and connectivity patterns are causally linked to tinnitus.