Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy · 2026
Influence of hypoxic conditions on Trichosporon asahii virulence in a Galleria mellonella infection model.
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Sadamoto Sota, Abe Masahiro, Amemiya Kazuki, Koizumi Ami, Otani Amato, Oiki Sayoko, Shinohara Takayuki, Shibuya Kazutoshi, Miyazaki Yoshitsugu
Аннотация
OBJECTIVE: Trichosporon spp. Cause disseminated infections in immunosuppressed patients, primarily those with neutropenia. Microbial translocation from the gastrointestinal tract and entities from the inserted catheter are the main sources of bloodstream infections such as candidiasis, although the pathogenesis remains unclear. As human organs are hypoxic, we hypothesized that the hypoxic environment plays an important role in the pathogenesis of endogenous infections.
METHODS: We investigated the effect of a hypoxic environment on the pathogenesis of trichosporonosis using a Galleria mellonella infection model.
RESULTS: Infection by yeast precultured under hypoxic conditions (1% O2) led to shorter survival, a greater fungal burden in the hemolymph of G. mellonella, and significant filamentous growth in the histopathological examination compared with the findings for infection by yeast precultured under aerobic conditions.
CONCLUSIONS: In conclusion, lower oxygen environments might influence the pathogenicity of trichosporonosis.
METHODS: We investigated the effect of a hypoxic environment on the pathogenesis of trichosporonosis using a Galleria mellonella infection model.
RESULTS: Infection by yeast precultured under hypoxic conditions (1% O2) led to shorter survival, a greater fungal burden in the hemolymph of G. mellonella, and significant filamentous growth in the histopathological examination compared with the findings for infection by yeast precultured under aerobic conditions.
CONCLUSIONS: In conclusion, lower oxygen environments might influence the pathogenicity of trichosporonosis.