The European journal of surgery = Acta chirurgica · 1995
Exogenous phospholipid reduces postoperative peritoneal adhesions in rats.
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Ar'Rajab A, Snoj M, Larsson K, Bengmark S
Аннотация
OBJECTIVE: To find out if the previously described ability of phosphatidylcholine to reduce peritoneal adhesions is specific to it, or if other phospholipids such as phosphatidylinositol (PI) or DL-phosphatidylcholine dilauryl (DL-PC) have similar effects.
DESIGN: Laboratory experiment.
SETTING: University hospital, Sweden.
MATERIALS: 160 rats which had had intraperitoneal adhesions induced at laparotomy by peritoneal defects repaired in one of two models.
INTERVENTIONS: PI was given intraperitoneally either once in a dose of 20 or 40 mg/rat at the end of the operation, or at the end of the operation and repeated on the second and third postoperative days. DL-PC was given once at the end of the operation in a dose of either 20 or 40 mg/rat.
MAIN OUTCOME MEASURES: Adhesions were assessed a week after operation by an observer who was unaware of the treatment given.
RESULTS: PI given on three consecutive days significantly reduced adhesions formed postoperatively in both models (p < 0.05). Neither PI nor DL-PC given in a single dose of 20 mg/rat had any effect, whereas both PI and DL-PC given in single doses of 40 mg/rat significantly reduced adhesions (p < 0.05).
CONCLUSION: Both PI and DL-PC are effective in the prevention and limiting of postoperative adhesions in rats.
DESIGN: Laboratory experiment.
SETTING: University hospital, Sweden.
MATERIALS: 160 rats which had had intraperitoneal adhesions induced at laparotomy by peritoneal defects repaired in one of two models.
INTERVENTIONS: PI was given intraperitoneally either once in a dose of 20 or 40 mg/rat at the end of the operation, or at the end of the operation and repeated on the second and third postoperative days. DL-PC was given once at the end of the operation in a dose of either 20 or 40 mg/rat.
MAIN OUTCOME MEASURES: Adhesions were assessed a week after operation by an observer who was unaware of the treatment given.
RESULTS: PI given on three consecutive days significantly reduced adhesions formed postoperatively in both models (p < 0.05). Neither PI nor DL-PC given in a single dose of 20 mg/rat had any effect, whereas both PI and DL-PC given in single doses of 40 mg/rat significantly reduced adhesions (p < 0.05).
CONCLUSION: Both PI and DL-PC are effective in the prevention and limiting of postoperative adhesions in rats.