Acta oto-laryngologica · 2011
Cochlin-tomoprotein (CTP) detection test identifies traumatic perilymphatic fistula due to penetrating middle ear injury.
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Ikezono Tetsuo, Shindo Susumu, Sekine Kuwon, Shiiba Kyoko, Matsuda Han, Kusama Kaoru, Koizumi Yasuo, Sugizaki Kazuki, Sekiguchi Satomi, Kataoka Ryohei, Pawankar Ruby, Baba Shunkichi, Yagi Toshiaki, Okubo Kimihiro
Аннотация
CONCLUSIONS: The cochlin-tomoprotein (CTP) detection test can be used to make a definite, objective diagnosis of traumatic perilymphatic fistula (PLF), and therefore offers valuable information on patient selection for surgical treatment.
OBJECTIVES: Penetrating middle ear injury can cause traumatic PLF, which is a surgically treatable otologic emergency. Recently, we have reported on CTP, a novel perilymph-specific protein. The purpose of this study was to determine if the CTP detection test is useful for the diagnosis of traumatic PLF.
METHODS: This was a prospective study of CTP detection in penetrating middle ear injury cases with tympanic membrane perforation and hearing loss.
RESULTS: A total of seven individuals were included in this study. CTP was detected in three of four cases with posterosuperior quadrant perforation of the tympanic membrane. In one of these three cases, even though the high resolution CT scan was not suggestive of PLF and the perilymph leakage could not be visualized intraoperatively, the CTP detection test was able to detect PLF. In two cases, the preoperative positive test results enabled us to make a diagnosis of PLF and a decision for surgical treatment. CTP was not detected in the cases with anterior or inferior tympanic membrane perforation.
OBJECTIVES: Penetrating middle ear injury can cause traumatic PLF, which is a surgically treatable otologic emergency. Recently, we have reported on CTP, a novel perilymph-specific protein. The purpose of this study was to determine if the CTP detection test is useful for the diagnosis of traumatic PLF.
METHODS: This was a prospective study of CTP detection in penetrating middle ear injury cases with tympanic membrane perforation and hearing loss.
RESULTS: A total of seven individuals were included in this study. CTP was detected in three of four cases with posterosuperior quadrant perforation of the tympanic membrane. In one of these three cases, even though the high resolution CT scan was not suggestive of PLF and the perilymph leakage could not be visualized intraoperatively, the CTP detection test was able to detect PLF. In two cases, the preoperative positive test results enabled us to make a diagnosis of PLF and a decision for surgical treatment. CTP was not detected in the cases with anterior or inferior tympanic membrane perforation.
Предметные рубрики MeSH
AdultAudiometry, Pure-ToneBiomarkersBlotting, WesternBone ConductionChildEar, MiddleExtracellular Matrix ProteinsFemaleFistulaFollow-Up StudiesHearing Loss, ConductiveHumansImage Processing, Computer-AssistedLabyrinth DiseasesMaleMiddle AgedPerilymphPredictive Value of TestsProtein IsoformsProteomicsTomography, X-Ray ComputedTympanic Membrane PerforationVertigoWounds, Penetrating