Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology · 2007
Effects of ciprofloxacin/dexamethasone and ofloxacin on tympanic membrane perforation healing.
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Buyten Jeffrey, Kaufman Galen, Ryan Matthew
Аннотация
HYPOTHESIS: Exposure to ciprofloxacin/dexamethasone, but not ofloxacin, prolongs tympanic membrane (TM) healing.
BACKGROUND: Exposure to hydrocortisone has been shown to delay TM wound healing. No published studies have compared the effects of ciprofloxacin/dexamethasone and ofloxacin on TM healing.
METHODS: Noninfected TM perforations were created in 30 rats. The rats were split into three groups, and ciprofloxacin/dexamethasone, ofloxacin, or isotonic sodium chloride solution drops were instilled for 8 days. Tympanic membrane healing was analyzed at specified intervals using photographic documentation verified by a blinded observer.
RESULTS: The isotonic sodium chloride solution control and ofloxacin-exposed TMs healed at similar rates. There was a statistically significant delay in TM healing in the ciprofloxacin-/dexamethasone-exposed TMs by postoperative Day 10. However, all TM perforations were healed by postoperative Day 20.
CONCLUSION: Ciprofloxacin/dexamethasone delays healing of experimental TM perforations, but the brief exposure in this study did not cause persistent perforations.
BACKGROUND: Exposure to hydrocortisone has been shown to delay TM wound healing. No published studies have compared the effects of ciprofloxacin/dexamethasone and ofloxacin on TM healing.
METHODS: Noninfected TM perforations were created in 30 rats. The rats were split into three groups, and ciprofloxacin/dexamethasone, ofloxacin, or isotonic sodium chloride solution drops were instilled for 8 days. Tympanic membrane healing was analyzed at specified intervals using photographic documentation verified by a blinded observer.
RESULTS: The isotonic sodium chloride solution control and ofloxacin-exposed TMs healed at similar rates. There was a statistically significant delay in TM healing in the ciprofloxacin-/dexamethasone-exposed TMs by postoperative Day 10. However, all TM perforations were healed by postoperative Day 20.
CONCLUSION: Ciprofloxacin/dexamethasone delays healing of experimental TM perforations, but the brief exposure in this study did not cause persistent perforations.