Blood pressure · 2025
The role of epigenetics in hypertension of children and adolescents: a systematic review.
СтатьяСистематический обзорНазвание и аннотация: Перевод пока не подготовлен
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Sukesi Lilik, Sribudiani Yunia, Usman Steven Yulius, Yonatan Eric Ricardo, Widiasta Ahmedz, Indraswari Noormarina, Bandiara Ria, Soetedjo Nanny Nm
Аннотация
AIM: This systematic review study aimed to discuss about the possibility role of epigenetic in HTN of children and adolescent.
MATERIAL AND METHODS: This evidence-based research is implemented within the scope of the Preferred Reporting Item for Systematic Review and Meta-analysis (PRISMA) 2020. The data were analyzed qualitatively to assess the risk of bias, with the New Ottawa Scale (NOS) and Agency for Health Research and Quality (AHRQ) criteria as the thresholds. Our research highlights in particular showed that there is a role for epigenetics in HTN in children and adolescents.
CONCLUSION: Fourteen journals were included to be qualitatively assessed. Eleven journals (78.5%) stated that there was a correlation between epigenetic and BP in children and adolescents, however each study examined different genes or loci. In summary, epigenetic modifications of various single nucleotide polymorphisms (SNPs) and other genes were associated with higher systolic and diastolic BP in children and adolescents.
MATERIAL AND METHODS: This evidence-based research is implemented within the scope of the Preferred Reporting Item for Systematic Review and Meta-analysis (PRISMA) 2020. The data were analyzed qualitatively to assess the risk of bias, with the New Ottawa Scale (NOS) and Agency for Health Research and Quality (AHRQ) criteria as the thresholds. Our research highlights in particular showed that there is a role for epigenetics in HTN in children and adolescents.
CONCLUSION: Fourteen journals were included to be qualitatively assessed. Eleven journals (78.5%) stated that there was a correlation between epigenetic and BP in children and adolescents, however each study examined different genes or loci. In summary, epigenetic modifications of various single nucleotide polymorphisms (SNPs) and other genes were associated with higher systolic and diastolic BP in children and adolescents.