Annals of clinical and laboratory science · 2025
Effect of Serum IgE on Clinical Variables and Comorbidities Associated with Asthma Severity in Adults with Asthma in Brooklyn, New York.
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Smith-Norowitz Tamar A, Gold Yecheskel, Norowitz Esther M, Joks Rauno, Kohlhoff Stephan
Аннотация
OBJECTIVE: Elevated serum immunoglobulin (Ig)E levels are associated with increased asthma and atopy severity in adults. The aim of this study was to determine whether levels of serum IgE or allergic sensitization affected clinical variables and increased the risk of asthma severity in adults with asthma in Brooklyn, NY.
METHODS: Retrospective study of adults with moderate asthma and atopy (N=66, mean age 49+/-14 y/o, 75% female). The primary analysis assessed the relationship between total serum IgE, presence of specific IgE (skin prick test), and clinical variables (body mass index (BMI) and pulmonary function tests). Data preparation and analysis was conducted using SPSS (Version 28.0.1.1).
RESULTS: Subjects with elevated total serum IgE had higher levels of pulmonary obstruction/asthma severity (FEV1/FVC, mean difference: -5.62±3.4, P=0.05 and FEF25-75, mean difference: 15.49±9.5, P= 0.05) (T-test for equality of means). Mean BMI was higher in subjects with allergic sensitization versus those without (32.59±8.14 vs. 29.5±4.4, P=0.05).
CONCLUSION: In adults with asthma there was a trend observed toward an association of atopy with clinical variables, including decreased lung function and higher BMI. The presence of high serum IgE levels should be considered when assessing asthma outcomes.
METHODS: Retrospective study of adults with moderate asthma and atopy (N=66, mean age 49+/-14 y/o, 75% female). The primary analysis assessed the relationship between total serum IgE, presence of specific IgE (skin prick test), and clinical variables (body mass index (BMI) and pulmonary function tests). Data preparation and analysis was conducted using SPSS (Version 28.0.1.1).
RESULTS: Subjects with elevated total serum IgE had higher levels of pulmonary obstruction/asthma severity (FEV1/FVC, mean difference: -5.62±3.4, P=0.05 and FEF25-75, mean difference: 15.49±9.5, P= 0.05) (T-test for equality of means). Mean BMI was higher in subjects with allergic sensitization versus those without (32.59±8.14 vs. 29.5±4.4, P=0.05).
CONCLUSION: In adults with asthma there was a trend observed toward an association of atopy with clinical variables, including decreased lung function and higher BMI. The presence of high serum IgE levels should be considered when assessing asthma outcomes.