Biochimica et biophysica acta. Molecular basis of disease · 2025
Moderating role of fasting insulin on the levels of vitamin D in idiopathic central precocious puberty girls.
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Sun Jun, Xiao Ya, Jiang Shu-Qin, Zhang Hong-Ru, Shi Wen-Hui, Li Jin-Bo, Yang Ying, Wang Wei
Аннотация
BACKGROUND: Vitamin D deficiency (VDD) is a risk factor for idiopathic central precocious puberty (ICPP), but the mechanism is unclear. The association between Vitamin D (Vit D) and insulin indicates that fasting insulin (FINS) may play a role in the influence of Vit D on the occurrence of ICPP.
OBJECTIVE: This study aimed to investigate the role of FINS in the impact of Vit D on ICPP risk in girls.
METHODS: A retrospective analysis was conducted on 91 girls with ICPP and 47 girls with normal growth. Data on growth parameters, secondary sex characteristics, laboratory test results, and imaging results were collected. The moderating and mediating effects of FINS on the effect of Vit D on ICPP were analyzed.
RESULTS: Girls with ICPP had higher FINS and homeostasis model assessment of insulin resistance (HOMA-IR) score and lower Vit D levels than those of controls. Among the girls with ICPP, those with VDD had significantly higher FINS and HOMA-IR values than those with Vit D insufficiency (VDI) or sufficiency (VDS). Moderation analysis revealed that FINS influenced the effect of Vit D on ICPP risk in girls with VDD. Receiver operating characteristic (ROC) curve analysis indicated that in the VDD group, the combination of 25(OH)D and FINS had an area under the ROC curve (AUC) of 0.910 for diagnosing ICPP.
CONCLUSION: FINS can moderate the effect of Vit D on ICPP in girls with VDD, and a combined assessment of FINS and Vit D may aid in the early diagnosis in these girls.
OBJECTIVE: This study aimed to investigate the role of FINS in the impact of Vit D on ICPP risk in girls.
METHODS: A retrospective analysis was conducted on 91 girls with ICPP and 47 girls with normal growth. Data on growth parameters, secondary sex characteristics, laboratory test results, and imaging results were collected. The moderating and mediating effects of FINS on the effect of Vit D on ICPP were analyzed.
RESULTS: Girls with ICPP had higher FINS and homeostasis model assessment of insulin resistance (HOMA-IR) score and lower Vit D levels than those of controls. Among the girls with ICPP, those with VDD had significantly higher FINS and HOMA-IR values than those with Vit D insufficiency (VDI) or sufficiency (VDS). Moderation analysis revealed that FINS influenced the effect of Vit D on ICPP risk in girls with VDD. Receiver operating characteristic (ROC) curve analysis indicated that in the VDD group, the combination of 25(OH)D and FINS had an area under the ROC curve (AUC) of 0.910 for diagnosing ICPP.
CONCLUSION: FINS can moderate the effect of Vit D on ICPP in girls with VDD, and a combined assessment of FINS and Vit D may aid in the early diagnosis in these girls.