Nongestational Ovarian Choriocarcinoma with Precocious Puberty in a 7-Year-Old Girl: A Rare Case Report.

BACKGROUND

Nongestational ovarian choriocarcinoma (NGOC) is extremely rare, particularly in the pediatric population. Few case reports have discussed NGOC with precocious puberty and mentioned both tumor markers (β-human chorionic gonadotropin [hCG], alpha-fetoprotein, CA125) and the dynamics of gonadotropic and gonadal hormones.

CASE: A 7-year-old girl presented with early puberty and an abdominal mass. Laboratory tests revealed elevated estradiol, β-hCG, and CA125 levels, with suppressed luteinizing hormone and follicle-stimulating hormone. She was diagnosed with ovarian choriocarcinoma and precocious puberty. Following tumor resection, her hormone levels normalized, and symptoms resolved.

CONCLUSION

Pediatric ovarian choriocarcinomas are rare and may present with precocious puberty. Comprehensive endocrine evaluation, including serum hormone assays, is essential for diagnosis. Hormonal profiles in pediatric patients may differ from those in adults, with estradiol levels often being markedly elevated compared to age-specific reference ranges, and progesterone levels being relatively low.