Sleep medicine · 2025
Combined impact of obstructive sleep apnea and periodic limb movements on sleep parameters.
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Park Moon, Senel Gulcin Benbir, Modi Harshil, Jain Viraj, DelRosso Lourdes M
Аннотация
STUDY OBJECTIVES: This study examines the combined effects of Obstructive Sleep Apnea (OSA) and Periodic Limb Movements of Sleep (PLMS) on sleep parameters. Specifically, it aims to determine whether their co-occurrence exacerbates sleep fragmentation, reduces sleep efficiency, and alters restorative sleep stages compared to either condition alone.
METHODS: We retrospectively analyzed 581 adults undergoing polysomnography at UCSF Fresno. Subjects were categorized into three groups: OSA, PLMS, and OSA and PLMS. Sleep metrics, including Total Sleep Time (TST), Wake After Sleep Onset (WASO), and sleep stages (N1, N2, N3, REM), were compared across groups using Kruskal-Wallis tests and linear regression, adjusting for age.
RESULTS: The coexistence of OSA and PLMS was associated with a significant reduction in TST and a synergistic effect on deep sleep stages (N3) and REM, indicating amplified sleep disruption beyond additive effects. OSA and PLMS led to a marked increase in WASO and awakenings, although the impact on WASO was additive rather than synergistic.
CONCLUSIONS: These findings underscore the need for tailored treatment approaches when OSA and PLMS co-occur. Standard OSA treatments like CPAP may be insufficient, as they don't address PLMS-induced sleep fragmentation. Effective management of both conditions could improve sleep quality and mitigate associated health risks.
METHODS: We retrospectively analyzed 581 adults undergoing polysomnography at UCSF Fresno. Subjects were categorized into three groups: OSA, PLMS, and OSA and PLMS. Sleep metrics, including Total Sleep Time (TST), Wake After Sleep Onset (WASO), and sleep stages (N1, N2, N3, REM), were compared across groups using Kruskal-Wallis tests and linear regression, adjusting for age.
RESULTS: The coexistence of OSA and PLMS was associated with a significant reduction in TST and a synergistic effect on deep sleep stages (N3) and REM, indicating amplified sleep disruption beyond additive effects. OSA and PLMS led to a marked increase in WASO and awakenings, although the impact on WASO was additive rather than synergistic.
CONCLUSIONS: These findings underscore the need for tailored treatment approaches when OSA and PLMS co-occur. Standard OSA treatments like CPAP may be insufficient, as they don't address PLMS-induced sleep fragmentation. Effective management of both conditions could improve sleep quality and mitigate associated health risks.