Expert review of hematology · 2025
Diagnostic and prognostic values of the systemic immune-inflammation index in children with immune thrombocytopenia.
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Hu Shiyi, Kuang Wenyong, Li Wanli, Zhang Benshan
Аннотация
BACKGROUND: The diagnostic and prognostic value of the systemic immune inflammation (SII) index for immune thrombocytopenia (ITP) remains to be determined.
RESEARCH DESIGN AND METHODS: A retrospective analysis was conducted on 120 ITP children admitted to The Affiliated Children's Hospital of Xiangya School of Medicine, Central South University (Hunan Children's Hospital) between January 2017 and June 2022. A control group comprised 79 healthy children undergoing outpatient physical examinations during the same period. Based on recurrence within 2 years post-treatment, ITP children were categorized into recurrence and non-recurrence groups. Multivariate Cox regression analysis was conducted, and receiver operating characteristic curves and Kaplan-Meier curves were plotted.
RESULTS: ITP children exhibited significantly reduced SII. The SII index assisted in predicting ITP occurrence and recurrence within 2 years post-treatment. PLT count and SII were independent protective factors against disease recurrence within 2 years post-treatment in ITP patients. A decrease in SII increased the risk of disease recurrence within 2 years.
CONCLUSIONS: ITP children exhibit reduced SII index. The SII index can assist in the diagnosis of ITP and demonstrates strong predictive value for disease recurrence risk within 2 years post-treatment in ITP children.
RESEARCH DESIGN AND METHODS: A retrospective analysis was conducted on 120 ITP children admitted to The Affiliated Children's Hospital of Xiangya School of Medicine, Central South University (Hunan Children's Hospital) between January 2017 and June 2022. A control group comprised 79 healthy children undergoing outpatient physical examinations during the same period. Based on recurrence within 2 years post-treatment, ITP children were categorized into recurrence and non-recurrence groups. Multivariate Cox regression analysis was conducted, and receiver operating characteristic curves and Kaplan-Meier curves were plotted.
RESULTS: ITP children exhibited significantly reduced SII. The SII index assisted in predicting ITP occurrence and recurrence within 2 years post-treatment. PLT count and SII were independent protective factors against disease recurrence within 2 years post-treatment in ITP patients. A decrease in SII increased the risk of disease recurrence within 2 years.
CONCLUSIONS: ITP children exhibit reduced SII index. The SII index can assist in the diagnosis of ITP and demonstrates strong predictive value for disease recurrence risk within 2 years post-treatment in ITP children.