Clinical pediatrics · 2011
Changes in platelet count as a predictive tool in sickle cell acute vaso-occlusive crises: a pediatric study.
Оценочное исследованиеСтатьяНазвание и аннотация: Перевод пока не подготовлен
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Shanley Leticia A, Ebeling Myla, Titus M Olivia
Аннотация
OBJECTIVE: Studies have shown that platelets play an important role in the pathophysiology of vaso-occlusive crises (VOC) in sickle cell disease. This study investigates whether changes in platelet indices from baseline can be predictive of complications during acute pain crisis.
METHODS: Data were obtained from pediatric sickle cell patients in the well-clinic setting and compared with data gathered during VOC (n = 67). Primary outcome was complicated (admission, acute chest syndrome, transfusion, etc) versus uncomplicated (discharge from emergency department without subsequent return) course.
RESULTS: Patients with uncomplicated courses had larger platelet declines (53.7) than those with complicated courses (14.8, P = .005).
CONCLUSIONS: The study suggests that patients with uncomplicated VOC are more likely to experience a larger decline in platelets. The predictive value is limited by the need to have preexisting steady-state data and relatively small decline. Ongoing studies are needed to identify useful laboratory data to help predict severity of VOC.
METHODS: Data were obtained from pediatric sickle cell patients in the well-clinic setting and compared with data gathered during VOC (n = 67). Primary outcome was complicated (admission, acute chest syndrome, transfusion, etc) versus uncomplicated (discharge from emergency department without subsequent return) course.
RESULTS: Patients with uncomplicated courses had larger platelet declines (53.7) than those with complicated courses (14.8, P = .005).
CONCLUSIONS: The study suggests that patients with uncomplicated VOC are more likely to experience a larger decline in platelets. The predictive value is limited by the need to have preexisting steady-state data and relatively small decline. Ongoing studies are needed to identify useful laboratory data to help predict severity of VOC.