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Войти в исследования Amyloid pathology and vascular risk are associated with distinct patterns of cerebral white matter hyperintensities: A multicenter study in 3132 memory clinic patients.
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Biesbroek J Matthijs, Coenen Mirthe, DeCarli Charles, Fletcher Evan M, Maillard Pauline M, Alzheimer's Disease Neuroimaging Initiative, Barkhof Frederik, Barnes Josephine, Benke Thomas, Chen Christopher P L H, Dal-Bianco Peter, Dewenter Anna, Duering Marco, Enzinger Christian, Ewers Michael, Exalto Lieza G, Franzmeier Nicolai, Hilal Saima, Hofer Edith, Koek Huiberdina L, Maier Andrea B, McCreary Cheryl R, Papma Janne M, Paterson Ross W, Pijnenburg Yolande A L, Rubinski Anna, Schmidt Reinhold, Schott Jonathan M, Slattery Catherine F, Smith Eric E, Sudre Carole H, Steketee Rebecca M E, Teunissen Charlotte E, van den Berg Esther, van der Flier Wiesje M, Venketasubramanian Narayanaswamy, Venkatraghavan Vikram, Vernooij Meike W, Wolters Frank J, Xin Xu, Kuijf Hugo J, Biessels Geert Jan
Аннотация
METHODS: Individual patient data (n = 3,132; mean age 71.5 ± 9 years; 49.3% female) from 11 memory clinic cohorts were harmonized. WMH volumes in 28 regions were related to a vascular risk compound score (VRCS) and Aß42 status (based on cerebrospinal fluid or amyloid positron emission tomography), correcting for age, sex, study site, and total WMH volume.
RESULTS: VRCS was associated with WMH in anterior/superior corona radiata (B = 0.034/0.038, p < 0.001), external capsule (B = 0.052, p < 0.001), and middle cerebellar peduncle (B = 0.067, p < 0.001), and Aß42-positive status with WMH in posterior thalamic radiation (B = 0.097, p < 0.001) and splenium (B = 0.103, p < 0.001).
DISCUSSION: Vascular risk factors and Aß42 pathology have distinct signature WMH patterns. This regional vulnerability may incite future studies into how arteriolosclerosis and Aß42 pathology affect the brain's white matter.
HIGHLIGHTS: Key dementia etiologies may be associated with specific patterns of white matter hyperintensities (WMH). We related WMH locations to vascular risk and cerebral Aβ42 status in 11 memory clinic cohorts. Aβ42 positive status was associated with posterior WMH in splenium and posterior thalamic radiation. Vascular risk was associated with anterior and infratentorial WMH. Amyloid pathology and vascular risk have distinct signature WMH patterns.