International dental journal · 2025
Antibacterial Efficacy of Oregano-Carbon Nanotubes Coated Silk Sutures: An In Vitro Experimental Study.
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Gaber Menna S, Abouraya Nehal Loutfy, Habib Shaymaa I
Аннотация
INTRODUCTION: Microbial infections following surgery or other medical procedures are a major health issue. To avoid or reduce the risk of infections, research is now concentrated on creating novel drug-free materials with antibacterial qualities. Sutures coated with antimicrobial agents are one way to prevent surgical site infections.
AIM: To develop and characterize an oregano-carbon nanotubes/polycaprolactone (PCL)-chitosan composite coating and evaluate the antimicrobial activity of sutures coated with this formulation.
METHODS: The dipping solution was prepared, and characterization was performed using Fourier Transform infrared spectroscopy, gas chromatography-mass spectrometry, transmission electron microscope and scanning electron microscope. Antibacterial activity against E. coli and S. aureus was evaluated after 1, 3 and 5 days using the colony-forming unit (CFU).
RESULTS: Oregano-carbon nanotubes/PCL-chitosan composite coated sutures showed higher antibacterial activity compared to uncoated ones at all tested time intervals.
CONCLUSION: Oregano-carbon nanotubes/PCL-chitosan composite could be a promising candidate as a natural-derived suture coating to guard against surgical site infection.
CLINICAL RELEVANCE: This study highlights the potential use of oregano-carbon nanotubes/PCL-chitosan composite as a suture coating.
AIM: To develop and characterize an oregano-carbon nanotubes/polycaprolactone (PCL)-chitosan composite coating and evaluate the antimicrobial activity of sutures coated with this formulation.
METHODS: The dipping solution was prepared, and characterization was performed using Fourier Transform infrared spectroscopy, gas chromatography-mass spectrometry, transmission electron microscope and scanning electron microscope. Antibacterial activity against E. coli and S. aureus was evaluated after 1, 3 and 5 days using the colony-forming unit (CFU).
RESULTS: Oregano-carbon nanotubes/PCL-chitosan composite coated sutures showed higher antibacterial activity compared to uncoated ones at all tested time intervals.
CONCLUSION: Oregano-carbon nanotubes/PCL-chitosan composite could be a promising candidate as a natural-derived suture coating to guard against surgical site infection.
CLINICAL RELEVANCE: This study highlights the potential use of oregano-carbon nanotubes/PCL-chitosan composite as a suture coating.
Предметные рубрики MeSH
Nanotubes, CarbonAnti-Bacterial AgentsSuturesEscherichia coliStaphylococcus aureusOriganumChitosanCoated Materials, BiocompatiblePolyestersIn Vitro TechniquesSpectroscopy, Fourier Transform InfraredMicroscopy, Electron, ScanningGas Chromatography-Mass SpectrometryMicroscopy, Electron, TransmissionSilkSurgical Wound Infection