Skinmed · 2007
Bleomycin treatment for verrucae.
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Price Norman M
Аннотация
BACKGROUND: The treatment of verrucae with bleomycin injections has not become a routinely adopted form of therapy in dermatologic practice since its use was originally described in 1980 because of the adverse effects and complications that have been associated with it.
OBJECTIVES: The goal of this study was to demonstrate the results and the incidence of adverse effects from the use of bleomycin in clinical practice in a retrospective study of patients presenting with verrucae and to demonstrate the convenience and ease of the methodology that was used in obtaining these results.
METHODS: Patients' lesions were injected with bleomycin every 3 to 4 weeks until the lesions had been eliminated or the injections were discontinued because of adverse effects or complications.
RESULTS: There were 211 patients in the study, and 224 lesions were treated. After 1 treatment, 47.6% of the lesions were cleared; another 38.8%were cleared after 2 treatments; and another 9.8% were cleared after 3 treatments. In total, 96% of lesions were cleared after 5 treatments. A small number of temporary adverse effects were noted: 3 patients had local chemical cellulitis, 2 patients had formation of sterile abscesses, 1 patient had postinflammatory hyperpigmentation, and 1 patient had localized pain. No local or systemic complications were observed.
CONCLUSIONS: Therapy with intralesional bleomycin is a relatively rapid and convenient form of therapy, compared with other available treatments, from the point of view of both the patient and the physician.
OBJECTIVES: The goal of this study was to demonstrate the results and the incidence of adverse effects from the use of bleomycin in clinical practice in a retrospective study of patients presenting with verrucae and to demonstrate the convenience and ease of the methodology that was used in obtaining these results.
METHODS: Patients' lesions were injected with bleomycin every 3 to 4 weeks until the lesions had been eliminated or the injections were discontinued because of adverse effects or complications.
RESULTS: There were 211 patients in the study, and 224 lesions were treated. After 1 treatment, 47.6% of the lesions were cleared; another 38.8%were cleared after 2 treatments; and another 9.8% were cleared after 3 treatments. In total, 96% of lesions were cleared after 5 treatments. A small number of temporary adverse effects were noted: 3 patients had local chemical cellulitis, 2 patients had formation of sterile abscesses, 1 patient had postinflammatory hyperpigmentation, and 1 patient had localized pain. No local or systemic complications were observed.
CONCLUSIONS: Therapy with intralesional bleomycin is a relatively rapid and convenient form of therapy, compared with other available treatments, from the point of view of both the patient and the physician.