[Various approaches to treatment of dysentery in children].

The clinical process, etiological pattern and results of antibacterial therapy of dysentery in 1105 children were analyzed by hospital records for the last 25 years. Significant changes in the etiology of dysentery were revealed. In the 1960s Shigella flexneri prevailed (56.3 per cent) and in the 1970-1990s Shigella sonnei prevailed (69.9 to 74.6 per cent) whereas the percentage of Newcastle dysentery was low and stable (1.5 to 8.7 per cent). Simultaneously, there were changes in antibiotic sensitivity of the Shigella strains. In the 1960s the Shigella strains were mainly sensitive to tetracyclines, in the 1970s they were mainly sensitive to levomycetin and polymyxin and in the 1980-1990s they were mainly sensitive to gentamicin, polymyxin, carbenicillin and ampicillin. Accordingly, the antibacterial therapy allowed for the sensitivity of the pathogen at the particular period. Biological preparations such as bifidum bacterin, bificol, lactobacterin, etc. should be used in the complex therapy of Shigella infection due to frequent affection of intestinal biocenosis.