Head & neck · 2016
Cigarette use, comorbidities, and prognosis in a prospective head and neck squamous cell carcinoma population.
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Peterson Lisa A, Bellile Emily L, Wolf Gregory T, Virani Shama, Shuman Andrew G, Taylor Jeremy M G, Rozek Laura S, University of Michigan Head and Neck Specialized Program of Research Excellence Program
Аннотация
BACKGROUND: To better understand the associations between a history of tobacco use and survival outcomes, cigarette use was prospectively surveyed in 687 previously untreated patients with cancer of the oral cavity (n = 271), oropharynx (n = 257), larynx (n = 135), or hypopharynx (n = 24).
METHODS: Kaplan-Meier and Cox models explored the associations of tobacco use intensity (packs/day), duration (years of use), and timing before diagnosis with overall survival (OS), disease-specific survival (DSS), and recurrence-free survival (RFS).
RESULTS: Cigarette use duration, timing, and intensity were significant predictors for all outcomes in univariate analysis. Never smoking and pack-years were not significantly associated with outcomes after adjustment for prognostic factors, such as stage, comorbidities, and human papillomavirus (HPV) status, which were strongly associated with clinical outcomes.
CONCLUSION: The findings confirm the association between smoking history and survival and the importance of clinical variables in evaluating smoking as a prognostic factor. Timing, intensity, and duration of cigarette use should be considered with other prognostic factors when considering risk stratification for treatment planning. © 2016 Wiley Periodicals, Inc. Head Neck 38: 1810-1820, 2016.
METHODS: Kaplan-Meier and Cox models explored the associations of tobacco use intensity (packs/day), duration (years of use), and timing before diagnosis with overall survival (OS), disease-specific survival (DSS), and recurrence-free survival (RFS).
RESULTS: Cigarette use duration, timing, and intensity were significant predictors for all outcomes in univariate analysis. Never smoking and pack-years were not significantly associated with outcomes after adjustment for prognostic factors, such as stage, comorbidities, and human papillomavirus (HPV) status, which were strongly associated with clinical outcomes.
CONCLUSION: The findings confirm the association between smoking history and survival and the importance of clinical variables in evaluating smoking as a prognostic factor. Timing, intensity, and duration of cigarette use should be considered with other prognostic factors when considering risk stratification for treatment planning. © 2016 Wiley Periodicals, Inc. Head Neck 38: 1810-1820, 2016.
Предметные рубрики MeSH
Age DistributionCarcinoma, Squamous CellCause of DeathCigarette SmokingCohort StudiesComorbidityDisease-Free SurvivalFemaleHead and Neck NeoplasmsHumansKaplan-Meier EstimateMalePrevalencePrognosisProportional Hazards ModelsProspective StudiesRisk AssessmentSex DistributionSquamous Cell Carcinoma of Head and NeckSurvival Analysis