Associations between blood cell profiles and low-to-medium myopia in school-aged children: a case-control study.

This prospective case-control study aimed to assess the relationships between blood count-derived inflammation indices and low-to-medium myopia in school-aged children. A total of 100 subjects aged 7–12 years were enrolled, including 49 emmetropic controls and 51 children with low-to-medium myopia (spherical equivalent ≤ -0.5 D and > -6.0 D). Various blood count parameters were assessed, including white blood cell count, neutrophil count, lymphocyte count, monocyte count, eosinophil count, basophil count, neutrophil percentage (N%), monocyte percentage (M%), lymphocyte percentage (L%), lymphocyte-to-monocyte ratio (LMR), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR). The mean N%, M%, NLR, and PLR were significantly greater in the myopia group than in the control group (p = 0.010, p = 0.013, p = 0.003, and p = 0.011, respectively), while the mean L%and LMR were significantly lower (p = 0.003 and p = 0.010, respectively). The area under the receiver operating characteristic curve (AUROC) values for N%, L%, M%, LMR, NLR, and PLR in distinguishing myopia from emmetropia were 0.658, 0.679, 0.631, 0.681, 0.674 and 0.683, respectively. These findings indicate that N%, L%, M%, NLR, PLR, and LMR are associated with low-to-medium myopia in school-aged children, suggesting a potential link between systemic inflammation and the development of myopia in this population.