Journal of affective disorders · 2017
The left middle temporal gyrus in the middle of an impaired social-affective communication network in social anxiety disorder.
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Yun Je-Yeon, Kim Jae-Chang, Ku Jeonghun, Shin Jung-Eun, Kim Jae-Jin, Choi Soo-Hee
Аннотация
BACKGROUND: Previous studies on patients diagnosed with social anxiety disorder (SAD) reported changed patterns of the resting-state functional connectivity network (rs-FCN) between the prefrontal cortices and other prefrontal, amygdalar or striatal regions. Using a graph theory approach, this study explored the modularity-based community profile and patterns of inter-/intra-modular communication for the rs-FCN in SAD.
METHODS: In total, for 28 SAD patients and 27 healthy controls (HC), functional magnetic resonance imaging (fMRI) data were acquired in resting-state and subjected to a graph theory analysis.
RESULTS: The within-module degree z-score for a hub region [out of a total of 10 hub regions ranked using the participation coefficient] named left middle temporal gyrus was impaired in SAD compared to HC, proportional to the severity of clinician-scored and patient-reported functional impairment in SAD.
LIMITATIONS: Most of participants included in this study were undergraduate students in their early-to-mid 20's.
CONCLUSIONS: This study showed the importance of functional communication from the left middle temporal gyrus with other opercular-insular-subcortical regions for better objective functioning and lesser subjective disability in SAD.
METHODS: In total, for 28 SAD patients and 27 healthy controls (HC), functional magnetic resonance imaging (fMRI) data were acquired in resting-state and subjected to a graph theory analysis.
RESULTS: The within-module degree z-score for a hub region [out of a total of 10 hub regions ranked using the participation coefficient] named left middle temporal gyrus was impaired in SAD compared to HC, proportional to the severity of clinician-scored and patient-reported functional impairment in SAD.
LIMITATIONS: Most of participants included in this study were undergraduate students in their early-to-mid 20's.
CONCLUSIONS: This study showed the importance of functional communication from the left middle temporal gyrus with other opercular-insular-subcortical regions for better objective functioning and lesser subjective disability in SAD.