Epilepsia · 2026
Executive dysfunction and employment in epilepsy.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Hauger Lisa E, Helmstaedter Christoph, Lossius Morten I, Alfstad Kristin Å, Molteberg Ellen, Torgersen Halvor, Skogan Annette H
Аннотация
OBJECTIVE: Executive dysfunction, affective symptoms, and unemployment are prevalent in patients with epilepsy, yet the relation between these variables remains poorly understood. The present study examined: (1) The relationship between epilepsy-related variables, affective symptoms, and executive functions (EFs); and (2) how these variables may be associated with participation in employment or education.
METHODS: Retrospective study including 559 patients admitted to the Norwegian National Centre for Epilepsy. EFs was assessed using EpiTrack, and affective symptoms were evaluated with the 7-item Generalized Anxiety Disorder (GAD-7) and Neurological Disorders Depression Inventory for Epilepsy (NDDI-E).
RESULTS: Impaired EFs were observed in half of the patients, and were associated with a higher antiseizure medication (ASM) load, even after adjusting for variables related to disease severity. Approximately 36% of the patients reported symptoms indicating major depression and 19% reported symptoms indicating generalized anxiety. Half of the sample was unemployed, and these patients showed poorer EFs than those engaged in employment or education (F(3, 530) = 12.29, p < .001, ηp2 = .07), with no group differences in seizure frequency, anxiety, or depressive symptoms.
SIGNIFICANCE: In patients at a tertiary epilepsy center, executive dysfunction is prevalent along with heightened symptoms of depression and anxiety. Executive dysfunction is associated with a higher ASM load as well as increased likelihood of unemployment. Our findings suggest that job retention may depend on more than the burden of epilepsy alone, with executive functioning playing a critical role. These findings emphasize the importance of monitoring EF during treatment adjustments and support minimizing total ASM load whenever possible to promote better functional outcomes.
METHODS: Retrospective study including 559 patients admitted to the Norwegian National Centre for Epilepsy. EFs was assessed using EpiTrack, and affective symptoms were evaluated with the 7-item Generalized Anxiety Disorder (GAD-7) and Neurological Disorders Depression Inventory for Epilepsy (NDDI-E).
RESULTS: Impaired EFs were observed in half of the patients, and were associated with a higher antiseizure medication (ASM) load, even after adjusting for variables related to disease severity. Approximately 36% of the patients reported symptoms indicating major depression and 19% reported symptoms indicating generalized anxiety. Half of the sample was unemployed, and these patients showed poorer EFs than those engaged in employment or education (F(3, 530) = 12.29, p < .001, ηp2 = .07), with no group differences in seizure frequency, anxiety, or depressive symptoms.
SIGNIFICANCE: In patients at a tertiary epilepsy center, executive dysfunction is prevalent along with heightened symptoms of depression and anxiety. Executive dysfunction is associated with a higher ASM load as well as increased likelihood of unemployment. Our findings suggest that job retention may depend on more than the burden of epilepsy alone, with executive functioning playing a critical role. These findings emphasize the importance of monitoring EF during treatment adjustments and support minimizing total ASM load whenever possible to promote better functional outcomes.