The Journal of speech and hearing disorders · 1985
Effects of glycerol on cochlear frequency selectivity in patients with Menière's disease.
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Harrison R V, Dauman R, Tavartkiladze G A, Aran J M
Аннотация
During transtympanic electrocochleography, action potential (AP) tuning curves were derived as a measure of cochlear frequency selectivity. In 18 out of 21 patients with symptoms of Menière's disease, a poor frequency selectivity was observed. In 12 subjects the effects on frequency selectivity of oral glycerol were measured, and in 5 patients AP tuning curves indicated an improvement in sharpness of tuning by a factor of 1.5-2.5. These changes started approximately 30 min after oral glycerol administration. In 2 subjects there was a deterioration in AP tuning. In 5 patients no significant changes were observed.