MedElevator
Войти в исследования Journal of affective disorders · 2025
Distinct electroencephalogram microstate in patients with methamphetamine use disorder and obsessive-compulsive disorder.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Zhu Rongrong, Tian Yang, Jiang Linjun, Qu Mengqian, Wang Dongmei, Zhang Xiangyang
Аннотация
BACKGROUND: Electroencephalogram (EEG) microstates reflect momentary localized brain activity and may indicate spontaneous fluctuations within large-scale neural networks. Methamphetamine use disorder (MUD) and obsessive-compulsive disorder (OCD) exhibit overlapping compulsive features, however, similarities or differences in whole-brain dynamics on subsecond timescales between patients with MUD and OCD remain unclear.
METHODS: We recruited 127 subjects aged 16 to 55 years, including 45 OCD patients, 44 MUD patients and 39 healthy controls (HCs), and collected resting-state EEG data. The OCD symptoms were assessed using the Yale-Brown Obsessive-Compulsive Scale (Y-BOCS), and drug craving in MUD was evaluated with the Drug Desire Questionnaire (DDQ).
RESULTS: Compared to HCs, MUD patients showed reduced time coverage of microstate A. OCD patients exhibited lower time coverage and occurrence of microstate A than MUD patients, alongside altered transition probabilities (reduced B/C/D → A; increased B → D) (all p < 0.05). In OCD, compulsion subscale scores were negatively correlated with B → D transition probability and the mean duration of microstate D, but positively correlated with the occurrence of microstate C (all p < 0.05). For MUD, DDQ desire and intention scores were positively correlated with the occurrence and time coverage of microstate D (all p < 0.05).
CONCLUSIONS: Our findings reveal that distinct EEG microstate patterns in MUD and OCD, shedding light on the underlying neurodynamic and connectivity differences between the two disorders. The relationship between microstate D and clinical symptoms in both disorders further elucidates potential shared neural underpinnings. Microstate C shows potential as a neurophysiological biomarker for OCD.
METHODS: We recruited 127 subjects aged 16 to 55 years, including 45 OCD patients, 44 MUD patients and 39 healthy controls (HCs), and collected resting-state EEG data. The OCD symptoms were assessed using the Yale-Brown Obsessive-Compulsive Scale (Y-BOCS), and drug craving in MUD was evaluated with the Drug Desire Questionnaire (DDQ).
RESULTS: Compared to HCs, MUD patients showed reduced time coverage of microstate A. OCD patients exhibited lower time coverage and occurrence of microstate A than MUD patients, alongside altered transition probabilities (reduced B/C/D → A; increased B → D) (all p < 0.05). In OCD, compulsion subscale scores were negatively correlated with B → D transition probability and the mean duration of microstate D, but positively correlated with the occurrence of microstate C (all p < 0.05). For MUD, DDQ desire and intention scores were positively correlated with the occurrence and time coverage of microstate D (all p < 0.05).
CONCLUSIONS: Our findings reveal that distinct EEG microstate patterns in MUD and OCD, shedding light on the underlying neurodynamic and connectivity differences between the two disorders. The relationship between microstate D and clinical symptoms in both disorders further elucidates potential shared neural underpinnings. Microstate C shows potential as a neurophysiological biomarker for OCD.