Journal of medical virology · 2025

A Comprehensive Molecular and Serological Investigation of Hepatitis A Virus Among Patients With Suspected Acute Hepatitis: A Brazilian Study.

СтатьяНаблюдательное исследованиеМногоцентровое исследованиеПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди

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de Oliveira Ketty Gleyzer, Vasconcelos Mariana Pinheiro Alves, Ton Julia Teixeira, Uehara Silvia Naomi de Oliveira, Sitnik Roberta, Ornelas Pereira Salvador de Oliveira Denize, Castberg Layze, Siqueira Ricardo Andreotti, Robinson Peter James, Domingues Thaís Senna de Paula, Panico Caroline Thomas, Inoue César Augusto, Maluf Maira Marranghello, de Mello Malta Fernanda, Amgarten Deyvid, Dorlass Erick, Sebe Pedro, Pinto Arlene S, Lobato Cirley M D O, Ferreira Adalgisa, Hyppolito Elodie, Paraná Raymundo, Schinoni Maria Isabel, Lopes Edmundo Pessoa de Almeida, Luiz Magali C, Garcia Raquel F L, Bertolini Dennis Armando, Álvares-da-Silva Mário Reis, Arrojo Raul Salinas, Emerim Eduardo, Coral Gabriela P, Acosta Paulo R, Lucena Marcello, Teixeira Rosângela, Guedes Mônica da Costa, Villar Livia Melo, Ximenez Lia Lewis, Gdalevici Clarice, Mendes-Correa Maria Cássia Jacintho, Carrilho Flair José, de Oliveira Gerson Sobrinho Salvador, Ferreira Paulo Roberto A, Ferraz Maria Lucia Gomes, Nastri Ana Catharina de Seixas Santos, Munoz Torres Pablo Andres, Selegatto Glória, Casadio Luciana Vilas Boas, Tenore Simone, Leite Olavo Henrique Munhoz, Souza Fernanda Fernandes, Reuter Tania, Souto Francisco, Nascimento-Sales Michele, Gurski Ana Paula Maciel, Salomão Andréa, Fanis Bruna Emanuelle Alvarenga, Pimenta Maria Cristina, de Almeida Elton Carlos, de Souza Flávia Moreno Alves, Pereira Gerson Fernando Mendes, Gonzalez Mario Peribañez, Gomes-Gouvea Michele Soares, de Azevedo Raymundo Soares, Pinho João Renato Rebello

Аннотация

Hepatitis A Virus (HAV) infects millions of individuals annually and is a major cause of acute viral hepatitis worldwide. This study aims to (1) assess HAV infection in suspected acute hepatitis patients at public healthcare institutions in Brazil; (2) evaluate the proportion of immunized individuals against HAV; (3) identify HAV genotypes; (4) examine the association between HAV infection and demographic data, as well as exposure to risk factors. This is a prospective, observational multicenter study conducted in primary health services in Brazil from October 2019 to May 2023, involving 1721 patients with suspected acute hepatitis. Acute HAV infection was identified in 108 (6.3%) patients, predominantly in young men (80%) and from South and Southeast regions of Brazil (97%). Anti-HAV IgG, indicating previous exposure or vaccination, was detected in 78.6% of individuals (74% in the South to 91% in the North). Genotype I.A was found in all cases and approximately 450 mutations were identified, most of them in the structural proteins VP1-3. Two viral groups were identified and related to two introductions of the virus: cosmopolitan sequences from North America, South America, and Europe, and a minor group of Brazilian sequences similar to Asian and South American ones. The high incidence of acute HAV infections highlights the need for targeted prevention and vaccination strategies. The characterization of HAV genetic diversity and molecular epidemiology contributes to monitoring and identifying emerging outbreaks.

A Comprehensive Molecular and Serological Investigation of Hepatitis A Virus Among Patients With Suspected Acute Hepatitis: A Brazilian Study.

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