Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
Cerebellar volumes' selective association with MoCA over MMSE: a diagnostic insight into mild cognitive impairment and mild dementia.
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Devita Maria, Ceolin Chiara, Begliomini Chiara, Sarlo Michela, Coin Alessandra, Bertoldo Alessandra, Sergi Giuseppe, Mapelli Daniela, De Rui Marina
Аннотация
INTRODUCTION: Linked to motor control, cerebellum is increasingly recognized for its role in cognition and neurodegenerative disorders.
METHODS: This retrospective study investigates associations between cerebellar volumes and cognitive screening tools-the Mini-Mental State Examination (MMSE) and the Montreal Cognitive Assessment (MoCA)-in individuals with mild cognitive impairment (MCI) or mild dementia.
RESULTS: MoCA scores showed significant positive correlations with cognitive-related cerebellar regions, particularly the left Crus I lobule (r = 0.40, p = 0.02) and total Crus I volume (r = 0.36, p = 0.04). Regression analysis confirmed associations with the left Crus I (β = 0.08, p = 0.02) and right VIIB lobule (β = 0.033, p = 0.032), while MMSE scores correlated only with right Lobule X thickness (r = -0.35, p = 0.04).
DISCUSSION: These findings suggest MoCA may better detect cerebellar-related cognitive impairments, underscoring the importance of including cerebellar evaluation in the early diagnosis of dementia.
METHODS: This retrospective study investigates associations between cerebellar volumes and cognitive screening tools-the Mini-Mental State Examination (MMSE) and the Montreal Cognitive Assessment (MoCA)-in individuals with mild cognitive impairment (MCI) or mild dementia.
RESULTS: MoCA scores showed significant positive correlations with cognitive-related cerebellar regions, particularly the left Crus I lobule (r = 0.40, p = 0.02) and total Crus I volume (r = 0.36, p = 0.04). Regression analysis confirmed associations with the left Crus I (β = 0.08, p = 0.02) and right VIIB lobule (β = 0.033, p = 0.032), while MMSE scores correlated only with right Lobule X thickness (r = -0.35, p = 0.04).
DISCUSSION: These findings suggest MoCA may better detect cerebellar-related cognitive impairments, underscoring the importance of including cerebellar evaluation in the early diagnosis of dementia.