[Characteristics of resting state functional magnetic resonance imaging in tinnitus patients with different degrees of affective disorder].

Objective

To analyze the correlation of the degree of affective disorder and brain function changes by comparing the differences of resting-state functional Magnetic Resonance Imaging（rs-fMRI） between healthy volunteers without tinnitus and patients with tinnitus. Method:A analysis of 19 patients with tinnitus and 15 healthy volunteers without tinnitus. The patients were divided into mild group and severe group according to tinnitus handicap inventory（THI）. Rs-fMRI was collected and the regional homogeneity（ReHo） analysis, amplitude of low-frequency fluctuation（ALFF） analysis, and fractional amplitude of low frequency fluctuation（fALFF） analysis of rs-fMRI were performed by DPABI software. Two-sample t-test of the ReHo value, ALFF value and fALFF value between the mild group and the control group, the severe group and the control group, were performed respectively. Result:The fALFF value of the left occipital gyrus in the mild group was higher than that in the control group, the difference was statistically significant（P<0.05）, but there is no statistically significant difference of ALFF value and ReHo value between two groups. The ALFF value of the middle temporal gyrus（left）, superior frontal gyrus（right）, inferior frontal gyrus pars triangularis（left） and caudate nucleus（left） in the severe group were higher than those of the control group. But there was no significant difference in the fALFF value and the ReHo value.

Conclusion

Different severity of affective disorder in patients with tinnitus have different areas of brain function abnormalities. Mild group was detected by fALFF analysis and the active brain area was the left middle occipital region. Severe group was detected by ALFF analysis. The active brain regions were left middle temporal gyrus, right superior frontal gyrus, left inferior frontal gyrus pars triangularis, and left caudate nucleus.