Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
Cognitive profiles at presentation and subsequent cognitive decline and quality of life in Parkinson's disease.
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Mirza Saira S, Duff-Canning Sarah, Mapstone Mark, Fox Susan, Black Sandra E, Binns Malcolm A, Breen David P, Fishman Keera N, Grimes David A, Lang Anthony E, Levine Brian, McLaughlin Paula M, Troyer Angela K, Masellis Mario, Marras Connie
Аннотация
INTRODUCTION: Currently, our ability to predict cognitive decline in Parkinson's disease is limited.
METHODS: In 234 dementia-free PD patients, cognitive profiles at baseline were determined using cluster analysis and longitudinal associations with global cognitive z-score, health-related quality of life (HR-QoL), caregiver burden, and risk of reliable cognitive change (RCC) were tested.
RESULTS: Participants fell into four cognitive profiles at baseline: normal cognition (n = 108), memory impairment (n = 47), memory and executive function impairment (n = 59), and global cognitive impairment (n = 20). After adjusting for the severity of cognitive impairment, only the memory impairment cluster showed a higher risk of RCC. Baseline cognitive profiles did not predict different rates of cognitive decline, change in HR-QoL, or caregiver burden.
DISCUSSION: The memory impairment cluster showed a higher risk of developing a reliable cognitive change; however, baseline cognitive profiles did not consistently predict different rates of cognitive decline, HR-QoL, or caregiver burden.
HIGHLIGHTS: Data-driven approach to identify cognitive profiles. Cognitive decline across domains assessed by risk of reliable cognitive change. Cognitive profiles did not predict rate of cognitive decline. Memory impairment profile had a higher risk of reliable cognitive change.
METHODS: In 234 dementia-free PD patients, cognitive profiles at baseline were determined using cluster analysis and longitudinal associations with global cognitive z-score, health-related quality of life (HR-QoL), caregiver burden, and risk of reliable cognitive change (RCC) were tested.
RESULTS: Participants fell into four cognitive profiles at baseline: normal cognition (n = 108), memory impairment (n = 47), memory and executive function impairment (n = 59), and global cognitive impairment (n = 20). After adjusting for the severity of cognitive impairment, only the memory impairment cluster showed a higher risk of RCC. Baseline cognitive profiles did not predict different rates of cognitive decline, change in HR-QoL, or caregiver burden.
DISCUSSION: The memory impairment cluster showed a higher risk of developing a reliable cognitive change; however, baseline cognitive profiles did not consistently predict different rates of cognitive decline, HR-QoL, or caregiver burden.
HIGHLIGHTS: Data-driven approach to identify cognitive profiles. Cognitive decline across domains assessed by risk of reliable cognitive change. Cognitive profiles did not predict rate of cognitive decline. Memory impairment profile had a higher risk of reliable cognitive change.