Nutritional neuroscience · 2011
Hippocampal plasticity in rats submitted to a gastric restrictive procedure.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
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Sonoda Elisa Yumi de Freitas, Gomes da Silva Sérgio, Arida Ricardo Mario, Giglio Pedro Nogueira, Margarido Nelson Fontana, Martinez Carlos Augusto Real, Pansani Aline Priscila, Maciel Rude de Souza, Cavalheiro Esper Abrão, Scorza Fulvio Alexandre
Аннотация
Bariatric surgery has been the most effective therapeutic intervention for morbidly obese patients. However, recent evidence has shown that this procedure may cause serious neurological complications such as Wernicke encephalopathy, depression, and memory impairment. With this in mind, we conducted an experimental study to investigate whether weight-reduction surgery would promote morphological changes in the hippocampal formation, a brain region linked to cognitive and emotional processes. To do so, the present study evaluated the hippocampal expression of parvalbumin interneurons in rats submitted to a gastric restrictive procedure (experimental phytobezoar). Our results demonstrated that rats with gastric-reduced capacity presented a significant increase in the expression of the parvalbumin interneurons in the hippocampal CA1 and CA3 subfields. These data are the first experimental evidence that restrictive bariatric surgery may alter hippocampal cytoarchitecture.