Clinical nutrition ESPEN · 2025
Age and sex but not disease activity or duration are associated with muscle mass in paediatric Crohn's disease.
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Aljilani Bayan, Yan Kaung, Naim Iyad, Darie Ana-Maria, Agbna Mustafa, Bahrin Muhammad H K, Tsintzas Kostas, Moran Gordon W
Аннотация
BACKGROUND: There is evidence of low muscle mass in adults with active Crohn's disease (CD) compared to patients in remission, but this has not been explored in paediatric CD.
AIM: To assess the psoas muscle cross sectional area (PCSA) measured using magnetic resonance enterography (MRE) in paediatric CD patients and compare this between those with active or inactive disease.
DESIGN: Paediatric CD patients who underwent MRE during 2016-2023 were included. Muscle mass was measured as PCSA at the right and left area of psoas muscle at the upper level of Lumbar 3 (L3) vertebra. Disease activity was defined by a clinical radiologist based on MRE images. Bivariable regression was used to explore unadjusted relationships, whereas a multiple linear regression model was constructed to adjust for potential confounders (disease activity, sex, age at MRE, disease duration, and current biologic use).
RESULTS: 107 patients with CD (57.9 % males) aged 13.0 (11.0, 15.0) [median (interquartile range)] were included. Most patients (64.5 %) had active disease and the median disease duration for the whole cohort was 0.97 (0.49, 3.07) years. There was no difference in PCSA between patients with active or inactive disease [25.06 (19.51, 33.99) and 26.51 (20.62, 36.99) cm2, respectively]. After adjusting for all covariates, the multivariable model identified sex and age at MRE as significant predictors of PCSA. Males had a 6.72 cm2 (-11.19, -2.25 cm2; p = 0.004) higher PCSA compared to females. For every 1-year increase in age, PCSA increased by 2.92 cm2 (2.04, 3.81; p < 0.001), adjusting for other covariates. Disease activity (p = 0.22), disease duration (p = 0.49) and current biologic use (p = 0.94) did not show significant associations with PCSA.
CONCLUSION: Age and sex but not disease activity or duration are significantly associated with muscle mass as measured by PCSA in paediatric CD.
AIM: To assess the psoas muscle cross sectional area (PCSA) measured using magnetic resonance enterography (MRE) in paediatric CD patients and compare this between those with active or inactive disease.
DESIGN: Paediatric CD patients who underwent MRE during 2016-2023 were included. Muscle mass was measured as PCSA at the right and left area of psoas muscle at the upper level of Lumbar 3 (L3) vertebra. Disease activity was defined by a clinical radiologist based on MRE images. Bivariable regression was used to explore unadjusted relationships, whereas a multiple linear regression model was constructed to adjust for potential confounders (disease activity, sex, age at MRE, disease duration, and current biologic use).
RESULTS: 107 patients with CD (57.9 % males) aged 13.0 (11.0, 15.0) [median (interquartile range)] were included. Most patients (64.5 %) had active disease and the median disease duration for the whole cohort was 0.97 (0.49, 3.07) years. There was no difference in PCSA between patients with active or inactive disease [25.06 (19.51, 33.99) and 26.51 (20.62, 36.99) cm2, respectively]. After adjusting for all covariates, the multivariable model identified sex and age at MRE as significant predictors of PCSA. Males had a 6.72 cm2 (-11.19, -2.25 cm2; p = 0.004) higher PCSA compared to females. For every 1-year increase in age, PCSA increased by 2.92 cm2 (2.04, 3.81; p < 0.001), adjusting for other covariates. Disease activity (p = 0.22), disease duration (p = 0.49) and current biologic use (p = 0.94) did not show significant associations with PCSA.
CONCLUSION: Age and sex but not disease activity or duration are significantly associated with muscle mass as measured by PCSA in paediatric CD.