Long-term evaluation of a historical cohort of Iranian common variable immunodeficiency patients.
Обработка статьи · этапы, ошибки и управление
Ошибки и ограничения
История · было → стало
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Aghamohammadi Asghar, Abolhassani Hassan, Latif AmirHossein, Tabassomi Firouzeh, Shokuhfar Tahaamin, Torabi Sagvand Babak, Shahinpour Shervin, Mirminachi Babak, Parvaneh Nima, Movahedi Masoud, Gharagozlou Mohammad, Sherkat Roya, Amin Reza, Aleyasin Soheila, Faridhosseini Reza, Jabbari-Azad Farahzad, Cheraghi Taher, Eslamian Mohamad Hosein, Khalili Abbas, Kalantari Najmoddin, Shafiei Alireza, Dabbaghzade Abbas, Khayatzadeh Alireza, Ebrahimi Mohsen, Razavinejad Davood, Bazregari Saeid, Ebrahimi Mehran, Ghaffari Javad, Bemanian Mohammad Hassan, Behniafard Nasrin, Kashef Sara, Mohammadzadeh Iraj, Hammarström Lennart, Rezaei Nima
Аннотация
METHODS: Diagnosis was made using approved criteria including reductions of serum levels of immunoglobulins and exclusion of well-known single gene defects in individuals with an age >4 years and evidence of specific antibody deficiency.
RESULTS: Detailed information on demographic data, survival rates, clinical phenotypes, immunologic and genetic data and treatment of 173 patients are provided. The early onset presentation (74.5%) and rate of consanguineous marriage (61.2%) were considerably higher in our cohort. Our study revealed clinically related correlations regarding consanguinity, the population of naïve CD4(+) T cells and switched-memory B cells, cytokine levels and special genetic factors (including HLA and AID genes).
CONCLUSION: Despite current efforts, more comprehensive studies are needed, especially for classification and investigation of the genetic background and prognostic factors for patients with CVID in order to better managment and followup of patinets.