Respiratory medicine · 2025
The bad bug: early MRSA infections in children with CF are associated with worse respiratory outcomes.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
García-Zapata Patricia Gabriella Rocha Carneiro, Takahashi Marcelo Straus, da Silva Filho Luiz Vicente Ribeiro Ferreira
Аннотация
BACKGROUND: Methicillin-resistant Staphylococcus aureus (MRSA) commonly occur in cystic fibrosis (CF) individuals with advanced disease, but their role in younger CF children is unknown. This study aimed to investigate clinical, functional, and radiological outcomes of CF children with early MRSA colonization.
METHODS: This retrospective cohort study compared CF individuals with MRSA isolation in cultures from respiratory secretions during the first 5 years of life (MRSA group) to age-matched controls. Data from the Brazilian CF Patient Registry and electronic medical records were used. Nutritional outcomes, lung function results between 6 and 7 years, and the first chest CT scan results were comparatively analysed. A linear regression model verified associations between MRSA identification before age 5 and potential confounders with lung function results.
RESULTS: The MRSA group (n = 32) had greater oral antibiotic exposure but similar hospital admission rates compared to controls (n = 49). The proportion of cultures with methicillin-sensitive S. aureus was greater in the control group (48 % vs 29.4 %, p = 0.009). The MRSA group had lower FEV1 (80.02 % vs 92.51 %, p = 0.023) and higher bronchiectasis scores on chest CT scans (1.9 vs 0.38, p = 0.031). MRSA identification before age 5 was significantly associated with an average 10.1 % (95 %CI -19.518 to -0.586, p = 0.038) decrease of FEV1.
CONCLUSIONS: Early MRSA identification was associated with increased exposure to antibiotics, higher bronchiectasis scores and lower FEV1 values at age 6. While these findings cannot define a relationship of causality, they provide insight into the associations between early MRSA infection and CF lung disease.
METHODS: This retrospective cohort study compared CF individuals with MRSA isolation in cultures from respiratory secretions during the first 5 years of life (MRSA group) to age-matched controls. Data from the Brazilian CF Patient Registry and electronic medical records were used. Nutritional outcomes, lung function results between 6 and 7 years, and the first chest CT scan results were comparatively analysed. A linear regression model verified associations between MRSA identification before age 5 and potential confounders with lung function results.
RESULTS: The MRSA group (n = 32) had greater oral antibiotic exposure but similar hospital admission rates compared to controls (n = 49). The proportion of cultures with methicillin-sensitive S. aureus was greater in the control group (48 % vs 29.4 %, p = 0.009). The MRSA group had lower FEV1 (80.02 % vs 92.51 %, p = 0.023) and higher bronchiectasis scores on chest CT scans (1.9 vs 0.38, p = 0.031). MRSA identification before age 5 was significantly associated with an average 10.1 % (95 %CI -19.518 to -0.586, p = 0.038) decrease of FEV1.
CONCLUSIONS: Early MRSA identification was associated with increased exposure to antibiotics, higher bronchiectasis scores and lower FEV1 values at age 6. While these findings cannot define a relationship of causality, they provide insight into the associations between early MRSA infection and CF lung disease.