BMJ open · 2021
Risk of pneumothorax in pneumoconiosis patients in Taiwan: a retrospective cohort study.
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Pan Jo-Hui, Cheng Chih-Hung, Wang Chao-Ling, Dai Chia-Yen, Sheu Chau-Chyun, Tsai Ming-Ju, Hung Jen-Yu, Chong Inn-Wen
Аннотация
OBJECTIVES: This study was conducted to explore the association between pneumoconiosis and pneumothorax.
DESIGN: Retrospective cohort study.
SETTING: Nationwide population-based study using the Taiwan National Health Insurance Database.
PARTICIPANTS: A total of 2333 pneumoconiosis patients were identified (1935 patients for propensity score (PS)-matched cohort) and matched to 23 330 control subjects by age and sex (7740 subjects for PS-matched cohort).
PRIMARY AND SECONDARY OUTCOME MEASURES: The incidence and the cumulative incidence of pneumothorax.
RESULTS: Both incidence and the cumulative incidence of pneumothorax were significantly higher in the pneumoconiosis patients as compared with the control subjects (p<0.0001). For multivariable Cox regression analysis adjusted for age, sex, residency, income level and other comorbidities, patients with pneumoconiosis exhibited a significantly higher risk of pneumothorax than those without pneumoconiosis (HR 3.05, 95% CI 2.18 to 4.28, p<0.0001). The male sex, heart disease, peripheral vascular disease, chronic pulmonary disease and connective tissue disease were risk factors for developing pneumothorax in pneumoconiosis patients.
CONCLUSIONS: Our study revealed a higher risk of pneumothorax in pneumoconiosis patients and suggested potential risk factors in these patients. Clinicians should be aware about the risk of pneumothorax in pneumoconiosis patients.
DESIGN: Retrospective cohort study.
SETTING: Nationwide population-based study using the Taiwan National Health Insurance Database.
PARTICIPANTS: A total of 2333 pneumoconiosis patients were identified (1935 patients for propensity score (PS)-matched cohort) and matched to 23 330 control subjects by age and sex (7740 subjects for PS-matched cohort).
PRIMARY AND SECONDARY OUTCOME MEASURES: The incidence and the cumulative incidence of pneumothorax.
RESULTS: Both incidence and the cumulative incidence of pneumothorax were significantly higher in the pneumoconiosis patients as compared with the control subjects (p<0.0001). For multivariable Cox regression analysis adjusted for age, sex, residency, income level and other comorbidities, patients with pneumoconiosis exhibited a significantly higher risk of pneumothorax than those without pneumoconiosis (HR 3.05, 95% CI 2.18 to 4.28, p<0.0001). The male sex, heart disease, peripheral vascular disease, chronic pulmonary disease and connective tissue disease were risk factors for developing pneumothorax in pneumoconiosis patients.
CONCLUSIONS: Our study revealed a higher risk of pneumothorax in pneumoconiosis patients and suggested potential risk factors in these patients. Clinicians should be aware about the risk of pneumothorax in pneumoconiosis patients.