Segmental cholestasis drives global hepatic fibrosis: lessons from the sBDL model in weaned rats.

This commentary provides a detailed analysis of Gonçalves et al.'s research paper, "Key genes and histopathological alterations in hepatic fibrogenesis after segmental cholestasis in weaned rats.1" It emphasizes how segmental cholestasis caused by selective bile duct ligation in young rats leads to extensive hepatic fibrogenesis, affecting both obstructed and non-obstructed liver lobes-similar to pediatric cholangiopathies like biliary atresia and post-transplant strictures in children. It not only illustrates regional hepatic disease patterns but also offers a valid preclinical platform for testing antifibrotic treatments.