Clinical imaging · 2012
Magnetic resonance imaging in the evaluation of iron overload: a comparison of MRI, echocardiography and serum ferritin level in patients with β-thalassemia major.
Сравнительное исследованиеСтатьяНазвание и аннотация: Перевод пока не подготовлен
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Shamsian Bibi Shahin, Esfahani Shadi Abdar, Milani Hani, Akhlaghpoor Shahram, Mojtahedzadeh Saeid, Karimi Abdollah, Shamshiri Ahmad Reza, Alavi Samin, Safari Alieh, Rezaei Nima, Arzanian Mohammad Taghi
Аннотация
PURPOSE: This study aimed to evaluate iron levels in cardiac and hepatic tissues using magnetic resonance imaging (MRI) T2*.
METHODS: Cardiac and hepatic MRI was performed for 93 patients with β-thalassemia major.
RESULTS: Cardiac T2* was in the range of 2.9-56.6 ms. Myocardial siderosis was detected in 44% of patients; 25 patients had moderate and severe siderosis with serum ferritin level (SFL) of 576-10,284 ng/ml. There was a significant correlation between SFL and cardiac T2* (p<.001).
CONCLUSIONS: The effective role of MRI as a noninvasive producible method in measurement of iron concentration in tissues is not accessible with conventional techniques.
METHODS: Cardiac and hepatic MRI was performed for 93 patients with β-thalassemia major.
RESULTS: Cardiac T2* was in the range of 2.9-56.6 ms. Myocardial siderosis was detected in 44% of patients; 25 patients had moderate and severe siderosis with serum ferritin level (SFL) of 576-10,284 ng/ml. There was a significant correlation between SFL and cardiac T2* (p<.001).
CONCLUSIONS: The effective role of MRI as a noninvasive producible method in measurement of iron concentration in tissues is not accessible with conventional techniques.