Effects of leukemic cells on hematopoiesis in radiation-induced murine erythroleukemia.

Erythroleukemia occurred in a BCF1 mouse after X-irradiation. This leukemia was maintained by leukemic cell transplantation successively without changes in the characters of leukemia. According to leukemic cell proliferation, peripheral blood leukemic cells increased in number, and anemia and granulocytopenia developed. Following leukemic cell infiltration, granuloid-committed stem cells (CFU-C) in bone marrow decreased but those in spleen increased. Neither leukemic cells nor leukemic cell-conditioned medium inhibited CFU-C culture in vitro. Effects of leukemic cells on hematopoiesis were discussed.