Clinical laboratory · 2013
Influence of low hemoglobin in children with iron deficiency anemia on PFA-100 testing.
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Akin Mehmet
Аннотация
BACKGROUND: Iron deficiency anemia may cause platelet aggregation dysfunction. The present study evaluated alterations of primary hemostasis in children with iron deficiency anemia caused by low hemoglobin using the PFA-100 instrument.
METHODS: This study analyzed 65 children between the ages of 2 and 14 with iron deficiency anemia (39 male and 26 female). The diagnosis criteria of IDA involved hemoglobin values below 11 g/dL, hematocrit values below 33%, erythrocyte counts below 3.7 x 10(12)/L, MCV values below 70 fL. Mean corpuscular hemoglobin (MCH) values below 27 pg, and ferritin levels below 12 ng/mL. Children without bleeding symptoms with blood hemoglobin values > 11g/dL and hematocrit values above 33%, defined in our previous study, were enrolled as the control group for the PFA-100 closure time. The ranges for prolonged C/EPI and C/ADP closure times in our center were > 160 seconds and > 110 seconds, respectively.
RESULTS: There was no significant correlation between hemoglobin values and C/EPI nor with C/ADP values.
CONCLUSIONS: This study found that low hemoglobin values do not play a role in obtaining C/EPI values above 160 seconds and C/ADP values above 110 seconds. We concluded that, patients with low hemoglobin values have no effect on the results of PFA-100, which is the screening test used to diagnose specific disorders such as von Willebrand disease or platelet secretion disorders.
METHODS: This study analyzed 65 children between the ages of 2 and 14 with iron deficiency anemia (39 male and 26 female). The diagnosis criteria of IDA involved hemoglobin values below 11 g/dL, hematocrit values below 33%, erythrocyte counts below 3.7 x 10(12)/L, MCV values below 70 fL. Mean corpuscular hemoglobin (MCH) values below 27 pg, and ferritin levels below 12 ng/mL. Children without bleeding symptoms with blood hemoglobin values > 11g/dL and hematocrit values above 33%, defined in our previous study, were enrolled as the control group for the PFA-100 closure time. The ranges for prolonged C/EPI and C/ADP closure times in our center were > 160 seconds and > 110 seconds, respectively.
RESULTS: There was no significant correlation between hemoglobin values and C/EPI nor with C/ADP values.
CONCLUSIONS: This study found that low hemoglobin values do not play a role in obtaining C/EPI values above 160 seconds and C/ADP values above 110 seconds. We concluded that, patients with low hemoglobin values have no effect on the results of PFA-100, which is the screening test used to diagnose specific disorders such as von Willebrand disease or platelet secretion disorders.