Neuroscience letters · 2003
Possible involvement of Wiskott-Aldrich syndrome protein family in aberrant neuronal sprouting in Alzheimer's disease.
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Kitamura Yoshihisa, Tsuchiya Daiju, Takata Kazuyuki, Shibagaki Keiichi, Taniguchi Takashi, Smith Mark A, Perry George, Miki Hiroaki, Takenawa Tadaomi, Shimohama Shun
Аннотация
One of the pathological characteristics of Alzheimer's disease (AD) is the formation of dystrophic neurites accompanied by aberrant neuronal sprouting. Although a number of studies have focussed on the formation of amyloid plaques and neurofibrillary tangles, the mechanism of neuronal sprouting in AD is not fully understood. The protein levels of neural Wiskott-Aldrich syndrome protein (N-WASP), WASP interacting SH3 protein (WISH) and WASP family verprolin-homologous protein (WAVE) were significantly increased in AD brains. In addition, N-WASP, WISH and WAVE were co-localized with filamentous actin in abnormal dendrite-like processes sprouting from staurosporine-treated human SH-SY5Y cells. These results suggest that N-WASP, WISH and WAVE may participate in the neurodegenerative aberrant sprouting in AD neurons.
Предметные рубрики MeSH
Adaptor Proteins, Signal TransducingAgedAged, 80 and overAlzheimer DiseaseBrainCarrier ProteinsHumansImmunoblottingImmunohistochemistryMicrofilament ProteinsMicroscopy, ConfocalMuscle ProteinsNerve Tissue ProteinsNeuronsStaurosporineTumor Cells, CulturedWiskott-Aldrich SyndromeWiskott-Aldrich Syndrome Protein FamilyWiskott-Aldrich Syndrome Protein, Neuronal