[Primary carcinoma of the liver following lymphoblastic leukemia in childhood (author's transl)].

A case of hepatocellular carcinoma following acute lymphoblastic leukemia (ALL) in childhood is described. After completion of the combined therapy of ALL, there was splenogenic thrombocytopenia which was successfully treated by splenectomy. Cirrhosis of the liver and HBs antigen-positive hepatitis was detected by biopsy. The cirrhosis progressed during the following year. After a further year a hepatocellular carcinoma was diagnosed. This gave rise to the death of the patient in complete hematological remission 5 years and 7 months after commencement and 2 years and 10 months after completion of the ALL therapy. Only two cases of hepatocellular carcinoma following ALL at this age have been reported by other authors.