Archives of general psychiatry · 2011
Higher-order genetic and environmental structure of prevalent forms of child and adolescent psychopathology.
СтатьяПоддержка NIH: внешняя программаTwin StudyНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Lahey Benjamin B, Van Hulle Carol A, Singh Amber L, Waldman Irwin D, Rathouz Paul J
Аннотация
CONTEXT: It is necessary to understand the etiologic structure of child and adolescent psychopathology to advance theory and guide future research.
OBJECTIVE: To test alternative models of the higher-order structure of etiologic effects on 11 dimensions of child and adolescent psychopathology using confirmatory factor analyses of genetic and environmental covariances.
DESIGN: Representative sample of twins.
SETTING: Home interviews.
PARTICIPANTS: A total of 1571 pairs of 9- to 17-year-old twins.
MAIN OUTCOME MEASURES: Structured assessments of psychopathology using adult caregivers and youth as informants.
RESULTS: The best-fitting genetic model revealed that most genetic factors nonspecifically influence risk for either all 11 symptom dimensions or for dimensions of psychopathology within 1 of 2 broad domains. With some notable exceptions, dimension-specific genetic influences accounted for modest amounts of variance.
CONCLUSIONS: To inform theory and guide molecular genetic studies, an etiologic model is offered in which 3 patterns of pleiotropy are hypothesized to be the principal modes of genetic risk transmission for common forms of child and adolescent psychopathology. Some common environmental influences were found, but consistent with a "generalist genes, specialist environments" model, there was little sharing of environmental influences. This implies that prevalent dimensions of child and adolescent psychopathology mostly share their genetic liabilities but are differentiated by nonshared experiences.
OBJECTIVE: To test alternative models of the higher-order structure of etiologic effects on 11 dimensions of child and adolescent psychopathology using confirmatory factor analyses of genetic and environmental covariances.
DESIGN: Representative sample of twins.
SETTING: Home interviews.
PARTICIPANTS: A total of 1571 pairs of 9- to 17-year-old twins.
MAIN OUTCOME MEASURES: Structured assessments of psychopathology using adult caregivers and youth as informants.
RESULTS: The best-fitting genetic model revealed that most genetic factors nonspecifically influence risk for either all 11 symptom dimensions or for dimensions of psychopathology within 1 of 2 broad domains. With some notable exceptions, dimension-specific genetic influences accounted for modest amounts of variance.
CONCLUSIONS: To inform theory and guide molecular genetic studies, an etiologic model is offered in which 3 patterns of pleiotropy are hypothesized to be the principal modes of genetic risk transmission for common forms of child and adolescent psychopathology. Some common environmental influences were found, but consistent with a "generalist genes, specialist environments" model, there was little sharing of environmental influences. This implies that prevalent dimensions of child and adolescent psychopathology mostly share their genetic liabilities but are differentiated by nonshared experiences.
Предметные рубрики MeSH
AdolescentAgoraphobiaAnxiety DisordersAttention Deficit Disorder with HyperactivityAttention Deficit and Disruptive Behavior DisordersChildConduct DisorderCross-Sectional StudiesMajor Depressive DisorderDiseases in TwinsFactor Analysis, StatisticalFemaleGenetic PleiotropyGenetic Predisposition to DiseaseGenetic VariationHumansIncidenceInternal-External ControlMaleMental DisordersModels, PsychologicalObsessive-Compulsive DisorderPhenotypePhobic DisordersRisk FactorsSocial Environment