Indocyanine green assists with sentinel lymph node mapping in pediatric and adolescent patients: A Pediatric Surgical Oncology Research Collaborative prospective observational study.
Обработка статьи · этапы, ошибки и управление
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Schermerhorn Sophia M V, Vore Emily, Bondoc Alexander J, Lautz Timothy B, Ayala Samantha A, Kastenberg Zachary J, Arkin Cameron, Malek Marcus M, Campwala Insiyah, Aldrink Jennifer H, Horvath Kyle Z, Piché Nelson, Osman Yasmin, Brown Erin G, Doyle Kathleen, Abril Paige, Roach Jonathan P, Ziogas Ioannis A, Rhee Daniel S, Chidiac Charbel, Polites Stephanie F, Debertin Julia, Craig Brian T, Lal Dave R, Kim Eugene S, Lee William G, Barkhordar Aaron, Le Hau D, Joshi Devashish, Stellon Michael, Tracy Elisabeth T, Beckhorn Catherine, Davies Dafydd A, Boehmer Chloé, Dasgupta Roshni
Аннотация
METHODS AND OBJECTIVES: Evaluate the safety and efficacy of ICG in SLN biopsy (SLNB) in diverse pediatric and AYA solid cancers in a multi-institutional environment. This is a prospective, observational study conducted at 13 member institutions in the Pediatric Surgical Oncology Research Collaborative between 2019 and 2023. Eligible patients underwent SLNB for primary or recurrent solid skin and soft tissue tumors. Peritumoral ICG was administered intraoperatively. Outcomes included SLN detection rates, histopathology of excised specimens, and surgeon-reported assessment of utility. Safety was assessed through adverse event reporting.
RESULTS: Forty SLNB procedures yielded 84 specimens: 13 melanoma (32.5%), 12 squamous cell carcinoma (30%), 11 non-rhabdomyosarcoma soft tissue sarcoma (27.5%), two rhabdomyosarcoma (5%), one Ewing sarcoma (2.5%), and one malignant peripheral nerve sheath tumor (2.5%). Histologic evaluation identified 81 lymph nodes, 75 benign (89.3%) and six malignant (7.1%); three specimens were adipose tissue (3.6%). Of 81 lymph nodes, 76% were ICG-positive. ICG had a sensitivity of 79.5%, a specificity of 33%, and a positive predictive value of 96%. All malignant nodes were ICG-avid. There were no adverse reactions to ICG at 30 days.
CONCLUSIONS: ICG is a safe and effective adjunct for SLNB in pediatric and AYA soft tissue and skin malignancies.