Advancements in APOE and dementia research: Highlights from the 2023 AAIC Advancements: APOE conference.
Обработка статьи · этапы, ошибки и управление
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Kloske Courtney M, Belloy Michael E, Blue Elizabeth E, Bowman Gregory R, Carrillo Maria C, Chen Xiaoying, Chiba-Falek Ornit, Davis Albert A, Paolo Gilbert Di, Garretti Francesca, Gate David, Golden Lesley R, Heinecke Jay W, Herz Joachim, Huang Yadong, Iadecola Costantino, Johnson Lance A, Kanekiyo Takahisa, Karch Celeste M, Khvorova Anastasia, Koppes-den Hertog Sascha J, Lamb Bruce T, Lawler Paige E, Guen Yann Le, Litvinchuk Alexandra, Liu Chia-Chen, Mahinrad Simin, Marcora Edoardo, Marino Claudia, Michaelson Danny M, Miller Justin J, Morganti Josh M, Narayan Priyanka S, Naslavsky Michel S, Oosthoek Marlies, Ramachandran Kapil V, Ramakrishnan Abhirami, Raulin Ana-Caroline, Robert Aiko, Saleh Rasha N M, Sexton Claire, Shah Nilomi, Shue Francis, Sible Isabel J, Soranno Andrea, Strickland Michael R, Tcw Julia, Thierry Manon, Tsai Li-Huei, Tuckey Ryan A, Ulrich Jason D, van der Kant Rik, Wang Na, Wellington Cheryl L, Weninger Stacie C, Yassine Hussein N, Zhao Na, Bu Guojun, Goate Alison M, Holtzman David M
Аннотация
METHODS: In 2023, the Alzheimer's Association convened multidisciplinary researchers at the "AAIC Advancements: APOE" conference to discuss various topics, including apoE isoforms and their roles in AD pathogenesis, progress in apoE-targeted therapeutic strategies, updates on disease models and interventions that modulate apoE expression and function.
RESULTS: This manuscript presents highlights from the conference and provides an overview of opportunities for further research in the field.
DISCUSSION: Understanding apoE's multifaceted roles in AD pathogenesis will help develop targeted interventions for AD and advance the field of AD precision medicine.
HIGHLIGHTS: APOE is a central player in the pathogenesis of Alzheimer's disease. APOE exerts a numerous effects throughout the brain on amyloid-beta, tau, and other pathways. The AAIC Advancements: APOE conference encouraged discussions and collaborations on understanding the role of APOE.