Cardiac Angiosarcoma.

Angiosarcoma is the most aggressive primary malignant cardiac tumor, typically involving the right atrium and characterized by its high invasiveness, rapid progression, and nonspecific clinical manifestations. The patient presented with recurrent hemorrhagic pericardial effusion and cardiac tamponade. Imaging revealed a right atrial mass, and intraoperative findings confirmed extensive invasion into the pericardium and adjacent structures, necessitating a partial palliative resection. Histopathological examination confirmed the diagnosis of angiosarcoma. After surgery, the patient received a combination regimen of chemotherapy, immunotherapy, and targeted therapy, with an overall survival of 11 months. A deeper understanding of this disease, clarification of the therapeutic challenges, and the development of evidence-based treatment guidelines are needed to provide more reliable and potentially life-saving strategies for patients with this disease.