The American journal of gastroenterology · 2024
The Minimally Invasive 1-Hour Esophageal String Test Monitors Therapeutic Changes in Mucosal Inflammation in Eosinophilic Esophagitis.
СтатьяПоддержка службы здравоохранения СШАНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Ackerman Steven J, Kagalwalla Amir F, Pan Zhaoxing, Wechsler Joshua, Keeley Kaitlin, Gonsalves Nirmala, Hirano Ikuo, Zalewski Angelika, Menard-Katcher Paul, Menard-Katcher Calies, Gupta Sandeep K, Chauhan Nikhil, Grozdanovic Milica, Atkins Dan, Nguyen Nathalie, Furuta Glenn T
Аннотация
INTRODUCTION: Endoscopy, standard-of-care for monitoring eosinophilic esophagitis (EoE), assesses mucosal inflammation. The Esophageal String Test (EST), a minimally invasive swallowed capsule and immunoassays, quantifies EoE inflammation. We determined whether the EST/EoEScore can monitor disease in patients undergoing treatment.
METHODS: Thirty-three samples from 14 patients with EoE (7 children, 7 adults) who underwent repeat endoscopies and ESTs were studied. Biopsies were analyzed for peak eosinophil counts; ESTs were analyzed for EoEScores.
RESULTS: Eosinophil counts and EoEScores significantly correlated during treatment, distinguishing patients with active EoE from treatment-associated remissions for 93.9% of ESTs performed.
DISCUSSION: The EST can be used to longitudinally monitor responses to treatment in EoE.
METHODS: Thirty-three samples from 14 patients with EoE (7 children, 7 adults) who underwent repeat endoscopies and ESTs were studied. Biopsies were analyzed for peak eosinophil counts; ESTs were analyzed for EoEScores.
RESULTS: Eosinophil counts and EoEScores significantly correlated during treatment, distinguishing patients with active EoE from treatment-associated remissions for 93.9% of ESTs performed.
DISCUSSION: The EST can be used to longitudinally monitor responses to treatment in EoE.