Plasma IL-17A is increased in patients with critical MIS-C and associated to in-hospital mortality.
Обработка статьи · этапы, ошибки и управление
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
de Farias Emmerson C F, do Nascimento Luciana M P P, Pavão Junior Manoel J C, Pavão Dalila C A, Pinheiro Ana P S, Pinheiro Andreza H O, Alves Marília C B, Ferraro Kíssila M M M, Aires Larisse F Q, Dias Luana G, Machado Mayara M M, Serrão Michaelle J D, Gomes Raphaella R, de Moraes Sara M P, Pontes Gabriela C L, Carvalho Railana D F P, Silva Cristiane T C, Neves Carla M A das, Dos Santos Joyce C L, de Sousa Adriana M B, da Silva Leda L, de Mello Mary L F M F, Carvalho Patricia B, Braga Renata de B, Harada Kathia de O, Justino Maria C A, Costa Iran B, Brasil-Costa Igor, Monteiro Marta C, Clemente Gleice, Terreri Maria Teresa
Аннотация
OBJECTIVES: The aim of this study is to study inflammatory biomarkers (cytokines and oxidative stress) in critical MIS-C patients and to observe if there is association between these biomarkers and mortality.
METHODS: A single-center prospective study enrolled patients with MIS-C (with positive molecular test), aged between 1 month and 18 years of age. Data was collected from 20 pediatric intensive care unit (PICU)'s bed. Inflammatory biomarkers (cytokines and oxidative stress markers) were performed on day 1 and 3 after hospitalization. Survival rate was calculated, and Kaplan-Meier curves were plotted. Univariate and multivariate Cox regression analyses were conducted. The ROC (Receiver Operating Characteristic) curve analysis was performed.
RESULTS AND CONCLUSIONS: A total of 41 patients out of 109 patients admitted at PICU with suspected MIS-C during the study period were included, of which 33 (80.5%) were male, 9 (22%) were under one year old, and 30 (73.2%) presented comorbidities. Among them, 16 (39%) did not survive. The mean survival time was shorter in patients with higher levels of IL-17A (≥ 19.71 pg/mL) on day 1 (115 vs 323 days, p = 0.004). Higher levels of IL-17A on day 1 were associated with mortality in both the crude model (HR 1.03, CI95% 1.004-1.057, p = 0.022) and the adjusted model (HR 1.043, CI95% 1.013-1.075, p = 0.012). ROC analysis revealed a cut-off value for the IL-17A of 14.32 pg/ml. The other immunological and inflammatory markers did not demonstrate an association with survival (p>0.05). Our findings suggest that patients with high levels of IL-17A are at greater risk for death.