Canadian journal of ophthalmology. Journal canadien d'ophtalmologie · 2012
Three-year visual and anatomic results of administrating intravitreal bevacizumab in inflammatory ocular neovascularization.
СтатьяМногоцентровое исследованиеНазвание и аннотация: Перевод пока не подготовлен
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Mansour Ahmad M, Arevalo J Fernando, Fardeau Christine, Hrisomalos Emily N, Chan Wai-Man, Lai Timothy Y Y, Ziemssen Focke, Ness Thomas, Sibai Abla Mehio, Mackensen Friederike, Wolf Armin, Hrisomalos Nicholas, Heiligenhaus Arnd, Spital Georg, Jo Yukari, Gomi Fumi, Ikuno Yasushi, Akesbi Jad, LeHoang Phuc, Adan Alfredo, Mahendradas Padmamalini, Khairallah Moncef, Guthoff Rainer, Ghandour Blanche, Küçükerdönmez Cem, Kurup Shree K
Аннотация
OBJECTIVE: To assess the 3-year visual outcome of intravitreal bevacizumab in inflammatory ocular neovascularization.
DESIGN: Experimental study.
METHODS: Retrospective multicenter consecutive case series in 81 patients with inflammatory ocular neovascularization refractory to standard therapy and treated with intravitreal bevacizumab. The outcome measures included improvement of best corrected visual acuity expressed as logarithm of minimum angle of resolution (logMAR) and paired comparison decrease in central foveal thickness by optical coherence tomography.
RESULTS: Mean best corrected visual acuity improved from baseline 0.699 (6/30 or 20/101) (SD 0.434) to 0.426 (6/16 or 20/53) (SD 0.428) (n = 81; p < 0.001), a gain of 2.7 lines (median 3 injections; 81 eyes; 81 patients). Paired comparisons revealed significant central foveal flattening at 3 years of 97.9 μm (n = 51; p < 0.001). In a subgroup analysis, visual improvement was significant for ocular histoplasmosis (p = 0.026); multifocal choroiditis (p = 0.05); serpiginous choroiditis (p = 0.028); ocular toxoplasmosis (p = 0.042); and punctate inner choroidopathy (p = 0.015). In a subgroup analysis, foveal flattening was significant for ocular histoplasmosis (p = 0.004); multifocal choroiditis (p = 0.007); serpiginous choroiditis (p = 0.011); and punctate inner choroidopathy (p = 0.001). Of the group, 5 eyes developed submacular fibrosis, 1 eye retinal pigment epithelial tear, and 1 eye macular ischemia in the context of vasculitis.
CONCLUSION: At 3 years, intravitreal bevacizumab sustained significant visual improvement of 2.7 lines and significant foveal flattening of 98 μm in a wide variety of inflammatory ocular diseases without major complications after a median of 3 injections.
DESIGN: Experimental study.
METHODS: Retrospective multicenter consecutive case series in 81 patients with inflammatory ocular neovascularization refractory to standard therapy and treated with intravitreal bevacizumab. The outcome measures included improvement of best corrected visual acuity expressed as logarithm of minimum angle of resolution (logMAR) and paired comparison decrease in central foveal thickness by optical coherence tomography.
RESULTS: Mean best corrected visual acuity improved from baseline 0.699 (6/30 or 20/101) (SD 0.434) to 0.426 (6/16 or 20/53) (SD 0.428) (n = 81; p < 0.001), a gain of 2.7 lines (median 3 injections; 81 eyes; 81 patients). Paired comparisons revealed significant central foveal flattening at 3 years of 97.9 μm (n = 51; p < 0.001). In a subgroup analysis, visual improvement was significant for ocular histoplasmosis (p = 0.026); multifocal choroiditis (p = 0.05); serpiginous choroiditis (p = 0.028); ocular toxoplasmosis (p = 0.042); and punctate inner choroidopathy (p = 0.015). In a subgroup analysis, foveal flattening was significant for ocular histoplasmosis (p = 0.004); multifocal choroiditis (p = 0.007); serpiginous choroiditis (p = 0.011); and punctate inner choroidopathy (p = 0.001). Of the group, 5 eyes developed submacular fibrosis, 1 eye retinal pigment epithelial tear, and 1 eye macular ischemia in the context of vasculitis.
CONCLUSION: At 3 years, intravitreal bevacizumab sustained significant visual improvement of 2.7 lines and significant foveal flattening of 98 μm in a wide variety of inflammatory ocular diseases without major complications after a median of 3 injections.
Предметные рубрики MeSH
AdolescentAdultAgedAngiogenesis InhibitorsAntibodies, Monoclonal, HumanizedBevacizumabChemotherapy, AdjuvantChildChoroidal NeovascularizationChoroiditisFemaleHumansImmunosuppressive AgentsIntravitreal InjectionsMaleMiddle AgedRetinaRetrospective StudiesTime FactorsTomography, Optical CoherenceTreatment OutcomeUveitisVascular Endothelial Growth Factor AVisual Acuity