Clinicopathological factors associated with progression of oral submucous fibrosis: A population-based retrospective study.

Oral submucosal fibrosis was one of the oral potentially malignant disorders, which has become a global epidemic disease. This study aimed to investigate the clinicopathological features associated with the disease progression of oral submucosal fibrosis. We recruited 700 cases of oral submucosal fibrosis in the Department of oral pathology, Xiangya Stomatological Hospital, Central South University from July 1996 to July 2019, and analyzed the association among staging of oral submucosal fibrosis and age, sex, sites, duration of areca nut chewing. The age of the patients ranged from 14 to 63 years, with a median age of 32 years. The average age of oral submucosal fibrosis in the early stage (35.89 ± 9.97) was different from the average age in the middle stage (32.74 ± 8.83) and advanced stage (31.43 ± 7.57, P < 0.05). The risk of staging progression of oral submucosal fibrosis decreased with age (OR = 0.965, 95%CI: 0.945-0.986, P = 0.001).