European journal of preventive cardiology · 2026
The diagnostic yield of an elaborate workup for comorbidities in a real-life heart failure with preserved ejection fraction outpatient population.
СтатьяНаблюдательное исследованиеНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Mourmans Sanne G J, Achten Anouk, Weerts Jerremy, Scheepers Marijne, Barandiarán Aizpurua Arantxa, Henkens Michiel, Uszko-Lencer Nicole, Brunner-La Rocca Hans-Peter, Knackstedt Christian, van Empel Vanessa P M
Аннотация
AIMS: Comorbidities play an important role in heart failure (HF) with preserved ejection fraction (HFpEF). Still, current guidelines lack clear directives for routine comorbidity screening and are primarily based on HF with reduced ejection fraction populations. This study evaluates the diagnostic yield of standardized routine workup for comorbidities in HFpEF. The goal is to provide clinicians with actionable insights to refine strategies for screening and managing HFpEF patients.
METHODS AND RESULTS: This single-centre prospective observational cohort study included patients diagnosed with HFpEF via a specialized outpatient clinic and evaluated the diagnostic yield of standardized diagnostic workup for comorbidities, including laboratory testing, sleep apnoea screening, 24 h Holter monitoring, spirometry, exercise testing, and 6 min walk test. A total of 501 HFpEF patients (age 75 ± 7 years, 67% female) were included. Before diagnostic workup, a median of three [2-5] comorbidities was known, and one additional comorbidity was diagnosed during standardized workup, most commonly sleep apnoea (33%) and iron deficiency (35%). Overall, the most prevalent comorbidities were hypertension (74%), sleep apnoea (52%), atrial fibrillation (50%), iron deficiency (49%), and obesity (45%). Pre-existing comorbidities did not receive optimal guideline-directed therapy, specifically diabetes (23%), hypercholesterolaemia (36%), and obesity (45%).
CONCLUSION: This study highlights the value of routine comorbidity screening in HFpEF, identifying one new comorbidity per patient on top of three pre-existing conditions, most commonly sleep apnoea or iron deficiency. Treatment of existing comorbidities was often suboptimal. Systematic screening not only improves the detection of undiagnosed conditions but also enables personalized and effective comorbidity management.
METHODS AND RESULTS: This single-centre prospective observational cohort study included patients diagnosed with HFpEF via a specialized outpatient clinic and evaluated the diagnostic yield of standardized diagnostic workup for comorbidities, including laboratory testing, sleep apnoea screening, 24 h Holter monitoring, spirometry, exercise testing, and 6 min walk test. A total of 501 HFpEF patients (age 75 ± 7 years, 67% female) were included. Before diagnostic workup, a median of three [2-5] comorbidities was known, and one additional comorbidity was diagnosed during standardized workup, most commonly sleep apnoea (33%) and iron deficiency (35%). Overall, the most prevalent comorbidities were hypertension (74%), sleep apnoea (52%), atrial fibrillation (50%), iron deficiency (49%), and obesity (45%). Pre-existing comorbidities did not receive optimal guideline-directed therapy, specifically diabetes (23%), hypercholesterolaemia (36%), and obesity (45%).
CONCLUSION: This study highlights the value of routine comorbidity screening in HFpEF, identifying one new comorbidity per patient on top of three pre-existing conditions, most commonly sleep apnoea or iron deficiency. Treatment of existing comorbidities was often suboptimal. Systematic screening not only improves the detection of undiagnosed conditions but also enables personalized and effective comorbidity management.