Cancer research · 2006
Overexpression of c-Maf contributes to T-cell lymphoma in both mice and human.
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Morito Naoki, Yoh Keigyou, Fujioka Yuki, Nakano Takako, Shimohata Homare, Hashimoto Yuko, Yamada Akiko, Maeda Atsuko, Matsuno Fumihiko, Hata Hiroyuki, Suzuki Atsushi, Imagawa Shigehiko, Mitsuya Hiroaki, Esumi Hiroyasu, Koyama Akio, Yamamoto Masayuki, Mori Naoyoshi, Takahashi Satoru
Аннотация
c-Maf translocation or overexpression has been observed in human multiple myeloma. Although c-maf might function as an oncogene in multiple myeloma, a role for this gene in other cancers has not been shown. In this study, we have found that mice transgenic for c-Maf whose expression was direct to the T-cell compartment developed T-cell lymphoma. Moreover, we showed that cyclin D2, integrin beta(7), and ARK5 were up-regulated in c-Maf transgenic lymphoma cells. Furthermore, 60% of human T-cell lymphomas (11 of 18 cases), classified as angioimmunoblastic T-cell lymphoma, were found to express c-Maf. These results suggest that c-Maf might cause a type of T-cell lymphoma in both mice and humans and that ARK5, in addition to cyclin D2 and integrin beta(7), might be downstream target genes of c-Maf leading to malignant transformation.